Chutivongse S, Wilde H, Supich C, Baer G M, Fishbein D B
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand.
Lancet. 1990 Apr 14;335(8694):896-8. doi: 10.1016/0140-6736(90)90488-q.
The Thai Red Cross intradermal postexposure rabies treatment schedule was prospectively assessed in 100 Thai patients severely bitten by proven rabid animals. It consists of 0.1 ml of purified Vero cell rabies vaccine containing more than 2.5 IU of rabies antigen per 0.5 ml of reconstituted vaccine given intradermally at two sites on days 0, 3, and 7, followed by one 0.1 ml injection on days 30 and 90. The commercial vaccine used had an antigen content of 3.17 IU per 0.5 ml ampoule. Purified equine or human rabies immuno-globulin was also given on day 0 to patients with severe exposures. As much of the immunoglobulin as possible was infiltrated around the wounds. All patients were followed for 1 year post exposure. There were no deaths; the efficacy of the regimen was 100%. Antibody titre determination in a randomly selected subgroup showed seroconversion in all 10 patients.
泰国红十字会皮内暴露后狂犬病治疗方案在100名被确诊患有狂犬病的动物严重咬伤的泰国患者中进行了前瞻性评估。该方案包括在第0、3和7天，在两个部位皮内注射0.1毫升纯化的Vero细胞狂犬病疫苗，每0.5毫升复溶疫苗中含狂犬病抗原超过2.5国际单位，随后在第30和90天各注射0.1毫升。所用的商业疫苗每0.5毫升安瓿的抗原含量为3.17国际单位。对于严重暴露的患者，也在第0天给予纯化的马或人狂犬病免疫球蛋白。尽可能多的免疫球蛋白浸润在伤口周围。所有患者暴露后随访1年。无死亡病例；该方案的疗效为100%。在一个随机选择的亚组中进行的抗体滴度测定显示，所有10名患者均出现血清转化。
