Kasempimolporn S, Hemachudha T, Khawplod P, Manatsathit S
Science Division, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok.
Clin Exp Immunol. 1991 May;84(2):195-9. doi: 10.1111/j.1365-2249.1991.tb08148.x.
Antibodies to two components of rabies virus, nucleocapsid (N) and glycoprotein (G), were compared in 11 rabies patients with those in nine recipients of Vero cell rabies vaccine. All rabies vaccinees had antibodies to N and G components by day 10 after the first vaccine injection. A similar but not identical response was observed in three out of 11 rabies patients. Serum antibodies appeared in rabies patients as early as 3 days after onset of the first symptoms of the disease. In these antibody-positive rabies patients, levels of both antibodies, but particularly of anti-N antibody, were lower than in the vaccinated group. Our results suggest that the process of immune recognition and of antibody development in human rabies is more likely to occur early in the pre-clinical phase, and that reactivity to N protein may be crucial for elicitation of neutralizing antibody.
在11名狂犬病患者中，对狂犬病毒的两种成分核衣壳（N）和糖蛋白（G）的抗体，与9名接种Vero细胞狂犬病疫苗的受种者体内的抗体进行了比较。所有狂犬病疫苗接种者在首次注射疫苗后第10天均产生了针对N和G成分的抗体。在11名狂犬病患者中有3名出现了类似但不完全相同的反应。狂犬病患者的血清抗体最早在疾病首发症状出现后3天就出现了。在这些抗体阳性的狂犬病患者中，两种抗体的水平，尤其是抗N抗体的水平，均低于接种疫苗组。我们的结果表明，人类狂犬病中免疫识别和抗体产生过程更有可能在临床前期早期发生，并且对N蛋白的反应性可能对中和抗体的产生至关重要。
