Institute of Community Medicine, University of Tromsø, 9037 Tromsø, Norway.
Osteoporos Int. 2010 Jun;21(6):931-8. doi: 10.1007/s00198-009-1035-6. Epub 2009 Aug 22.
In this longitudinal study of 4,137 persons, bone mineral density was negatively associated with osteoprotegerin at baseline in both genders. In postmenopausal women not using hormone replacement therapy (HRT), bone-loss increased with increasing osteoprotegerin levels, whereas no relationship was found in men, premenopausal women, or postmenopausal women taking HRT.
In a population-based study of 2,003 men and 2,134 women, the relationship between the osteoprotegerin (OPG)/factor-kappaB ligand (RANKL) system and bone mineral density (BMD) and changes in BMD was examined.
Baseline measurements included height, weight, BMD of the forearm, OPG, RANKL, vitamin D, and serum parathyroid hormone (PTH) and information about lifestyle, prevalent diseases, and use of medication. BMD was remeasured at follow-up 6 years later.
BMD was negatively associated with OPG at baseline in both men and women (p trend over OPG levels = 0.01 and 0.007, respectively, after adjustments for age, and other confounders). In postmenopausal women not on hormone replacement therapy, bone loss increased with increasing OPG (p = 0.005), whereas no relationship was found in men, premenopausal women, or postmenopausal women on HRT (p >or= 0.28). BMD at baseline and BMD changes were not related to RANKL levels in any of the groups (p >or= 0.14).
In postmenopausal women not using HRT, bone loss associated positively with OPG. The results indicate that in women deficient in sex steroids, the OPG/RANKL system may play an important counter regulatory role in order to avoid bone loss and maintain BMD. In men and women replete in sex steroids, the OPG/RANKL system was not associated with BMD.
本纵向研究纳入了 4137 人，结果显示，无论男性还是女性，基线时骨矿物质密度与护骨素呈负相关。在未使用激素替代疗法（HRT）的绝经后妇女中，随着护骨素水平的升高，骨丢失增加，而在男性、绝经前妇女或使用 HRT 的绝经后妇女中则未发现这种关系。
在一项基于人群的 2003 名男性和 2134 名女性的研究中，研究了护骨素（OPG）/核因子-κB 配体（RANKL）系统与骨矿物质密度（BMD）的关系以及 BMD 的变化。
基线测量包括身高、体重、前臂 BMD、OPG、RANKL、维生素 D、血清甲状旁腺激素（PTH）以及生活方式、现患疾病和药物使用情况。6 年后进行随访时重新测量 BMD。
无论男性还是女性，基线时 BMD 与 OPG 呈负相关（经年龄和其他混杂因素调整后，OPG 水平的趋势检验 p 值分别为 0.01 和 0.007）。在未接受激素替代疗法的绝经后妇女中，随着 OPG 的增加，骨丢失增加（p=0.005），而在男性、绝经前妇女或接受 HRT 的绝经后妇女中则未发现这种关系（p≥0.28）。在任何一组人群中，基线 BMD 和 BMD 变化与 RANKL 水平均无相关性（p≥0.14）。
在未使用 HRT 的绝经后妇女中，骨丢失与 OPG 呈正相关。这些结果表明，在缺乏性激素的女性中，OPG/RANKL 系统可能发挥重要的反向调节作用，以避免骨丢失并维持 BMD。在性激素充足的男性和女性中，OPG/RANKL 系统与 BMD 无关。
