对人类细小病毒B19基因组核苷酸序列的分析揭示了两种不同的进化模式，即逐渐改变和突然替换：一项对日本札幌1980年至2008年的回顾性研究。
Analysis of nucleotide sequences of human parvovirus B19 genome reveals two different modes of evolution, a gradual alteration and a sudden replacement: a retrospective study in Sapporo, Japan, from 1980 to 2008.
作者信息
Suzuki Masashi, Yoto Yuko, Ishikawa Aki, Tsutsumi Hiroyuki
机构信息
Department of Pediatrics, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan.
出版信息
J Virol. 2009 Nov;83(21):10975-80. doi: 10.1128/JVI.00273-09. Epub 2009 Aug 26.
Abstract
There have been no long-term systematic analyses of the molecular epidemiology of human parvovirus B19 (B19V). We investigated the variations of nucleotide sequences of B19V strains collected in Sapporo, Japan, from 1980 to 2008. In that period, six outbreaks of erythema infectiosum occurred regularly at 5-year intervals. The B19V strains collected successively, regardless of the outbreak, were analyzed for nucleotide variation in the subgenomic NS1-VP1u junction. The isolated strains can be classified into 10 subgroups. Two patterns of change of endemic strains were observed. One was a dynamic replacement of strains that occurred almost every 10 years, and the other was a gradual change consisting of an accumulation of point mutations.
摘要
此前尚未对人细小病毒B19（B19V）的分子流行病学进行长期系统分析。我们调查了1980年至2008年在日本札幌收集的B19V毒株的核苷酸序列变异情况。在此期间，传染性红斑每隔5年定期爆发6次。对连续收集的B19V毒株，无论是否为爆发期毒株，均分析其亚基因组NS1-VP1u连接区的核苷酸变异。分离出的毒株可分为10个亚组。观察到地方流行毒株有两种变化模式。一种是几乎每10年发生一次的毒株动态更替，另一种是由点突变积累构成的渐变。
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