Department of Urology and Andrology, Donauspital, SMZ-Ost, Langobardenstrasse 122, 1220, Vienna, Austria.
World J Urol. 2010 Dec;28(6):693-7. doi: 10.1007/s00345-009-0468-z. Epub 2009 Aug 27.
Prostate-specific antigen (PSA) is measured in circulating blood volume (BV), which is known to have a wide inter- and intraindividual variability. As data investigating the potential impact of different BV on PSA test validity are scant, we determined the relationship between BV and serum PSA values.
Men aged 41-60 years, participating in a health screening project, were evaluated. Serum samples of fasting patients were drawn between 8.00 and 10.00 a.m., all PSA measurements were determined in the same laboratory. Circulating BV was calculated according to the Retzlaff formula based on height, weight and haematocrit.
A total of 400 men with a mean age of 47.9 years entered the analysis. Mean PSA was 1.20 ng/ml (range 0.23-8.59 ng/ml) and mean BV was 3,370 ml (range 2,380-4,220 ml). Mean PSA values stratified from lowest to the highest third of BV were 1.22, 1.17 and 1.19 ng/ml in the total cohort. The respective figures for men aged 41-50 years were 1.08, 0.98 and 1.03 ng/ml, and for those aged 51-60 years: 1.47, 1.48 and 1.53 ng/ml. Neither BV nor three other related biometrical parameters (body mass index, waist-hip ratio, body fat percentage) revealed a correlation with the PSA values.
Our data suggest that BV does not have a significant impact on serum PSA values. To exclude a potential minor impact of BV on PSA, larger study cohorts, however, are required.
前列腺特异性抗原（PSA）在循环血量（BV）中进行测量，已知其具有广泛的个体间和个体内变异性。由于缺乏关于不同 BV 对 PSA 检测有效性潜在影响的数据，我们确定了 BV 与血清 PSA 值之间的关系。
评估年龄在 41-60 岁之间参加健康筛查项目的男性。空腹患者的血清样本在 8.00 至 10.00 之间抽取，所有 PSA 测量均在同一家实验室进行。根据身高、体重和红细胞压积的 Retzlaff 公式计算循环 BV。
共有 400 名年龄为 47.9 岁的男性进入分析。平均 PSA 为 1.20ng/ml（范围 0.23-8.59ng/ml），平均 BV 为 3370ml（范围 2380-4220ml）。根据 BV 从最低到最高三分之一分层的平均 PSA 值在总队列中分别为 1.22、1.17 和 1.19ng/ml。41-50 岁男性的相应数字分别为 1.08、0.98 和 1.03ng/ml，51-60 岁男性的相应数字分别为 1.47、1.48 和 1.53ng/ml。BV 及其他三个相关生物计量参数（体重指数、腰臀比、体脂百分比）均与 PSA 值无相关性。
我们的数据表明，BV 对血清 PSA 值没有显著影响。为了排除 BV 对 PSA 可能产生的轻微影响，需要更大的研究队列。
