肥胖和身高对非裔美国男性和白人男性前列腺特异性抗原（PSA）及游离PSA水平百分比的影响。
Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men.
作者信息
Fowke Jay H, Signorello Lisa B, Chang Sam S, Matthews Charles E, Buchowski Maciej S, Cookson Michael S, Ukoli Flora M, Blot William J
机构信息
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
出版信息
Cancer. 2006 Nov 15;107(10):2361-7. doi: 10.1002/cncr.22249.
BACKGROUND
Prior studies suggest that obese men have lower prostate-specific antigen (PSA) levels than leaner men. Caucasian (CA) men also may have lower PSA levels than African-American (AA) men, but the relevance of body size to racial disparities in PSA levels is unclear. The association between body mass index (BMI) and height on PSA and percentage of free PSA (%fPSA) was investigated within AA and CA men without a prior prostate cancer diagnosis.
METHODS
AA (n = 150) and CA (n = 149) men of similar socioeconomic status completed an extensive in-person interview and donated blood. PSA and %fPSA levels were compared across race, BMI, and height categories after adjusting for age and other factors.
RESULTS
PSA levels decreased with increasing BMI (PSA = .72, .69, .67, .59 ng/mL for BMI 18.5 to <25, 25 to <30, 30 to <35, and > or =35, respectively; P(trend) = .18), and trends were significant among men less than age 60 years (PSA = .81, .76, .66, .59, respectively; P(trend) = .02). fPSA also significantly decreased with BMI among men <60 years (P(trend) = .04). In contrast, %fPSA was not associated with BMI. However, %fPSA increased 27% across height categories (P(trend) = .02). PSA levels were significantly lower among CA men (PSA(AA) = 0.87, PSA(CA) = 0.63 ng/mL; P < .01), whereas %fPSA levels did not differ by race. Also, associations between body size and PSA or %fPSA did not significantly differ by race, and adjustment for BMI and height had no effect on the racial disparity in PSA (PSA(AA) = 0.87, PSA(CA) = 0.63 ng/mL; P < .01).
CONCLUSIONS
The data suggest that race, BMI, and height are independently associated with PSA and %fPSA levels.
背景
先前的研究表明，肥胖男性的前列腺特异性抗原（PSA）水平低于体型较瘦的男性。白人（CA）男性的PSA水平也可能低于非裔美国人（AA）男性，但体型与PSA水平种族差异之间的相关性尚不清楚。在未患前列腺癌的AA和CA男性中，研究了体重指数（BMI）和身高与PSA及游离PSA百分比（%fPSA）之间的关联。
方法
社会经济地位相似的AA男性（n = 150）和CA男性（n = 149）完成了一次广泛的面对面访谈并献血。在对年龄和其他因素进行校正后，比较了不同种族、BMI和身高类别的PSA和%fPSA水平。
结果
PSA水平随BMI的增加而降低（BMI为18.5至<25、25至<30、30至<35以及≥35时，PSA分别为0.72、0.69、0.67、0.59 ng/mL；P趋势 = 0.18），在60岁以下男性中趋势显著（PSA分别为0.81、0.76、0.66、0.59；P趋势 = 0.02）。在<60岁的男性中，fPSA也随BMI显著降低（P趋势 = 0.04）。相比之下，%fPSA与BMI无关。然而，%fPSA在不同身高类别中增加了27%（P趋势 = 0.02）。CA男性的PSA水平显著较低（PSA（AA） = 0.87，PSA（CA） = 0.63 ng/mL；P < 0.01），而%fPSA水平在不同种族之间没有差异。此外，体型与PSA或%fPSA之间的关联在不同种族之间没有显著差异，对BMI和身高进行校正对PSA的种族差异没有影响（PSA（AA） = 0.87，PSA（CA） = 0.63 ng/mL；P < 0.01）。结论：数据表明种族、BMI和身高与PSA和%fPSA水平独立相关。
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