Correia Marta, Machado José Carlos, Ristimäki Ari
Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias s/n, Porto, Portugal.
Helicobacter. 2009 Sep;14 Suppl 1:36-40. doi: 10.1111/j.1523-5378.2009.00696.x.
Gastric cancer is a worldwide health burden, which is still the second most common cause of cancer related deaths with little improvement of long-term survival during the past decades. Understanding the molecular nature of this disease and its precursor lesions has been under intense investigation and our review attempts to highlight recent progress in this field of cancer research. First, host-related genetic susceptibility is dealt with genes involved in inflammation and carcinogen metabolism. Next, role of overexpression of a proinflammatory cytokine (interleukin-1beta) and deletion of a cell-cell adhesion molecule (E-cadherin) are described in experimental mouse models of gastric carcinogenesis. Finally, the role of stem cells in gastric cancer is covered.
胃癌是一项全球性的健康负担，它仍然是癌症相关死亡的第二大常见原因，在过去几十年里长期生存率几乎没有改善。了解这种疾病及其癌前病变的分子本质一直是深入研究的课题，我们的综述试图突出癌症研究领域的最新进展。首先，宿主相关的遗传易感性涉及参与炎症和致癌物代谢的基因。其次，在胃癌发生的实验小鼠模型中描述了促炎细胞因子（白细胞介素-1β）过表达和细胞间粘附分子（E-钙粘蛋白）缺失的作用。最后，涵盖了干细胞在胃癌中的作用。
