Wang Liang, Wang XiaoHua, Kou HongJu, He HuiLiao, Lu Mingdong, Zhou LingLing, Yang Yan
Department of Ultrasound, The Second Affiliated Hospital and Yuying Children' s Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Oncotarget. 2017 Dec 22;9(9):8716-8724. doi: 10.18632/oncotarget.23819. eCollection 2018 Feb 2.
To evaluate the accuracy of double contrast-enhanced ultrasonography (DCEUS) in preoperative Borrmann classification of advanced gastric cancer (AGC).
A total of 162 patients histologically confirmed AGC were enrolled into this study. Single oral contrast-enhanced ultrasonography (SOCEUS) were performed in 80 patients and DCEUS (intravenous microbubbles combined with oral contrast-enhanced ultrasound) were performed in 82 patients preoperatively. The findings of the histopathologic examination of resected specimens after surgery were considered as gold standard. The accuracy of SOCEUS was compared with the accuracy of DCEUS in determining Borrmann classification. Interobserver agreement between two sonographyers of SOCEUS and DCEUS had also been assessed.
The accuracy of SOCEUS and DCEUS in Borrmann classification of advanced gastric cancer were 78.75% and 91.46% respectively. There was a significant difference between two methods (χ = 5.186, < 0.05). The interobserver agreement of two methods was both excellent for assessing the Borrmann classification with a Kappa value of 0.777 by SOCEUS and 0.844 by DCEUS.
DCEUS is a valuable method for Borrmann classification with its high accuracy preoperatively. It should be used widely.
评估双对比增强超声（DCEUS）在进展期胃癌（AGC）术前Borrmann分型中的准确性。
本研究共纳入162例经组织学确诊的AGC患者。80例患者术前行单纯口服对比增强超声（SOCEUS）检查，82例患者术前行DCEUS（静脉注射微泡联合口服对比增强超声）检查。手术切除标本的组织病理学检查结果被视为金标准。比较SOCEUS和DCEUS在确定Borrmann分型方面的准确性。还评估了SOCEUS和DCEUS的两位超声检查者之间的观察者间一致性。
SOCEUS和DCEUS在进展期胃癌Borrmann分型中的准确性分别为78.75%和91.46%。两种方法之间存在显著差异（χ = 5.186，<0.05）。两种方法在评估Borrmann分型方面的观察者间一致性均极佳，SOCEUS的Kappa值为0.777，DCEUS的Kappa值为0.844。
DCEUS术前准确性高，是Borrmann分型的一种有价值的方法，应广泛应用。
