胃癌患者循环肿瘤细胞的临床意义
Clinical significance of circulating tumor cells in gastric cancer patients.
作者信息
Zhou Jitao, Ma Xin, Bi Feng, Liu Ming
机构信息
Department of Medical Oncology/Laboratory of Signal Transduction & Molecular Targeted Therapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Oncotarget. 2017 Apr 11;8(15):25713-25720. doi: 10.18632/oncotarget.14879.
Abstract
Circulating tumor cells (CTCs) are rare cancer cells released from tumors into the blood stream that are thought to have a key role in cancer metastasis. Investigation of CTCs is an exciting area of research but remains in its infancy, and the presence of CTCs has been associated with worse prognosis in several major cancer types. Gastric cancer (GC) is a highly lethal malignancy and a serious public health concern in East Asia especially in China. There is an urgent need for identifying new, better prognostic markers to enhance diagnosis and prognosis, facilitate drug development, and to improve the treatment of gastric cancer patients. There are considerable interests in gastric CTCs given their potential use as gastric cancer biomarkers. This review highlights recent advances in studies of gastric CTCs, including the isolation and biological molecular characteristics of gastric CTCs, and their clinical significance.
摘要
循环肿瘤细胞（CTCs）是从肿瘤释放到血流中的罕见癌细胞，被认为在癌症转移中起关键作用。对CTCs的研究是一个令人兴奋的研究领域，但仍处于起步阶段，并且在几种主要癌症类型中，CTCs的存在与较差的预后相关。胃癌（GC）是一种高度致命的恶性肿瘤，在东亚尤其是中国，是一个严重的公共卫生问题。迫切需要识别新的、更好的预后标志物，以加强诊断和预后评估，促进药物开发，并改善胃癌患者的治疗。鉴于胃CTCs作为胃癌生物标志物的潜在用途，人们对其有相当大的兴趣。本综述重点介绍了胃CTCs研究的最新进展，包括胃CTCs的分离和生物学分子特征及其临床意义。
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本文引用的文献
1
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Oncotarget. 2016 Sep 13;7(37):59058-59069. doi: 10.18632/oncotarget.10175.
2
Dynamic monitoring of circulating tumour cells to evaluate therapeutic efficacy in advanced gastric cancer.动态监测循环肿瘤细胞以评估晚期胃癌的治疗效果。
Br J Cancer. 2016 Jan 19;114(2):138-45. doi: 10.1038/bjc.2015.417.
3
Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response.可切除胃癌患者上皮-间质转化循环肿瘤细胞的评估：与治疗反应的相关性
World J Gastroenterol. 2015 Dec 21;21(47):13259-67. doi: 10.3748/wjg.v21.i47.13259.
4
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5
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Int J Cancer. 2015 Aug 15;137(4):991-8. doi: 10.1002/ijc.29455. Epub 2015 Feb 13.
6
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Clin Chem. 2015 Jan;61(1):259-66. doi: 10.1373/clinchem.2014.228122. Epub 2014 Oct 21.
7
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8
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9
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.全球癌症发病与死亡：GLOBOCAN 2012 数据源、方法与主要模式。
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10
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