Institut de Biologie du Développement de Marseille-Luminy (IBDML), UMR 6216 CNRS-Université de la Méditerranée, Campus de Luminy, Marseille Cedex 09, France.
Curr Opin Genet Dev. 2009 Oct;19(5):518-25. doi: 10.1016/j.gde.2009.07.004. Epub 2009 Aug 28.
For the last 15 years the fly cardiovascular system has attracted developmental geneticists for its potential as a model system of organogenesis. Heart development in Drosophila indeed provides a remarkable system for elucidating the basic molecular and cellular mechanisms of morphogenesis and, more recently, for understanding the genetic control of cardiac physiology. The success of these studies can in part be attributed to multidisciplinary approaches, the multiplicity of existing genetic tools, and a detailed knowledge of the system. Striking similarities with vertebrate cardiogenesis have long been stressed, in particular concerning the conservation of key molecular regulators of cardiogenesis and the new data presented here confirm Drosophila cardiogenesis as a model not only for organogenesis but also for the study of molecular mechanisms of human cardiac disease.
在过去的 15 年中，果蝇的心血管系统因其作为器官发生模型系统的潜力而吸引了发育遗传学家。果蝇的心脏发育确实为阐明形态发生的基本分子和细胞机制，以及最近理解心脏生理学的遗传控制提供了一个极好的系统。这些研究的成功部分归因于多学科方法、现有的多种遗传工具以及对该系统的详细了解。长期以来，人们一直强调与脊椎动物心脏发生的惊人相似性，特别是在心脏发生的关键分子调节剂的保守性方面，这里呈现的新数据证实，果蝇心脏发生不仅是器官发生的模型，也是人类心脏疾病分子机制研究的模型。
