Gorfinkiel Nicole, Schamberg Sabine, Blanchard Guy B
Department of Genetics, University of Cambridge, CB2 3EH, Cambridge, United Kingdom.
Genesis. 2011 Jul;49(7):522-33. doi: 10.1002/dvg.20704. Epub 2011 Mar 5.
Although developmental biology has been dominated by the genetic analysis of embryonic development, in recent years genetic tools have been combined with new approaches such as imaging of live processes, automated and quantitative image analysis, mechanical perturbation and mathematical modeling, to study the principles underlying the formation of organisms. Here we focus on recent work carried out on Dorsal Closure, a morphogenetic process during Drosophila embryogenesis, to illustrate how this multidisciplinary approach is yielding new and unexpected insights into how cells organize themselves through the activity of their molecular components to give rise to the stereotyped and macroscopic movements observed during development.
尽管发育生物学一直以胚胎发育的遗传分析为主导，但近年来，遗传工具已与诸如实时过程成像、自动化定量图像分析、机械扰动和数学建模等新方法相结合，以研究生物体形成背后的原理。在这里，我们重点关注最近在果蝇胚胎发育过程中的一个形态发生过程——背闭合方面所开展的工作，以说明这种多学科方法如何为细胞如何通过其分子成分的活动自我组织，从而产生发育过程中观察到的定型宏观运动带来新的、意想不到的见解。
