百日咳博德特氏菌淋巴细胞增多促进因子对小鼠淋巴细胞的体外作用。I. 增殖反应。
The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes. I. Proliferative response.
作者信息
Kong A S, Morse S I
出版信息
J Exp Med. 1977 Jan 1;145(1):151-62. doi: 10.1084/jem.145.1.151.
Abstract
The lymphocytosis-promoting factor of Bordetella pertussis is a potent mitogen for murine lymphocytes in vitro. The stimulatory response was not the result of specific antigen stimulation. Spleen and lymph node cells were responsive, whereas normal thymocytes were unresponsive. However, DNA replication was induced in cortisone-resistant thymocytes by lymphocytosis-promoting factor (LPF). Bone marrow cells were not stimulated by LPF.
摘要
百日咳博德特氏菌的淋巴细胞增多促进因子在体外是鼠淋巴细胞的一种强效有丝分裂原。刺激反应并非特异性抗原刺激的结果。脾细胞和淋巴结细胞有反应，而正常胸腺细胞无反应。然而，淋巴细胞增多促进因子（LPF）可诱导可的松抗性胸腺细胞中的DNA复制。骨髓细胞不受LPF刺激。
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