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百日咳博德特氏菌淋巴细胞增多促进因子对小鼠淋巴细胞的体外作用:II. 反应细胞的性质

The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells.

作者信息

Kong A S, Morse S I

出版信息

J Exp Med. 1977 Jan 1;145(1):163-74. doi: 10.1084/jem.145.1.163.

Abstract

The mitogenic response of murine lymphocytes to the lymphocytosis-promoting factor of Bordetella pertussis has been shown to be due to activation of T cells. The selectivity of responsiveness to LPF with respect to the population of T cells which is stimllated, differs from that of PHA as well as Con A, and the surface receptors are different. A population of adherent cells, which does not appear to consist of macrophages or other phagocytic cells, is required for the T-cell response.

摘要

已证明小鼠淋巴细胞对百日咳博德特氏菌促淋巴细胞增多因子的促有丝分裂反应是由于T细胞的激活。LPF对受刺激的T细胞群体反应的选择性,不同于PHA以及Con A,且表面受体也不同。T细胞反应需要一群似乎并非由巨噬细胞或其他吞噬细胞组成的黏附细胞。

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