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H-2复合体I免疫反应基因区域中对鼠白血病的抗性基因。

Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex.

作者信息

Lonai P, Haran-Ghera N

出版信息

J Exp Med. 1977 Oct 1;146(4):1164-8. doi: 10.1084/jem.146.4.1164.

DOI:10.1084/jem.146.4.1164
PMID:197197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180826/
Abstract

A resistance locus to leukemogenesis in mice by A-RadLV (a variant of the radiation leukemia virus) is described. This locus, Rrv-1, was mapped to subregions I-A, I-B, and I-J of the H-2 complex. It is suggested that Rrv-1 may be in complementation with a second locus to the right of it, between Rrv-1 and H-2D. This localization and the complementation of the two loci for resistance are characteristics similar to Ir genes, and indicate a possible relationship between the genetic regulation of immune responsiveness and susceptibility to leukemia.

摘要

描述了小鼠中对A-RadLV（辐射白血病病毒的一种变体）致白血病作用的一个抗性位点。该位点Rrv-1被定位到H-2复合体的I-A、I-B和I-J亚区。有人提出，Rrv-1可能与其右侧位于Rrv-1和H-2D之间的第二个位点互补。这两个位点在抗性方面的这种定位和互补是与Ir基因相似的特征，表明免疫反应性的遗传调控与白血病易感性之间可能存在关联。

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本文引用的文献

1
On the natural history of the murine leukemias: presidential address.论鼠白血病的自然史：主席致辞
Cancer Res. 1967 Aug;27(8):1325-40.
2
Leukemia-associated transplantation antigens related to murine leukemia virus. The X.1 system: immune response controlled by a locus linked to H-2.与鼠白血病病毒相关的白血病相关移植抗原。X.1系统：由与H-2连锁的基因座控制的免疫反应。
J Exp Med. 1973 Sep 1;138(3):593-606. doi: 10.1084/jem.138.3.593.
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Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex.宿主对弗氏白血病病毒诱导的脾肿大恢复的遗传控制：主要组织相容性复合体内一个基因的定位
J Exp Med. 1974 Dec 1;140(6):1457-67. doi: 10.1084/jem.140.6.1457.
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The role of genetics in Gross virus leukemogenesis.遗传学在格罗斯病毒白血病发生中的作用。
Bibl Haematol. 1970(36):213-20. doi: 10.1159/000391710.
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Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
6
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.一个新的I亚区（I-J），由一个控制抑制性T淋巴细胞表面决定簇的基因座（Ia-4）标记。
J Exp Med. 1976 Sep 1;144(3):699-712. doi: 10.1084/jem.144.3.699.
7
Immunologic characteristics in relation to high and low leukemogenic activity of radiation leukemia virus variants. I. Cellular analysis of immunosuppression.与辐射白血病病毒变异体高低致白血病活性相关的免疫学特征。I. 免疫抑制的细胞分析。
J Immunol. 1977 Feb;118(2):600-6.
8
Kinetics of propagation of B-tropic murine leukemia virus on Fv-1b cell lines: requirement for multiple cycles of cell replication for transformation and viral antigen expression by RadLV.B型嗜性鼠白血病病毒在Fv-1b细胞系上的传播动力学：RadLV转化和病毒抗原表达对多个细胞复制周期的需求。
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