H-2复合体I免疫反应基因区域中对鼠白血病的抗性基因。
Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex.
作者信息
Lonai P, Haran-Ghera N
出版信息
J Exp Med. 1977 Oct 1;146(4):1164-8. doi: 10.1084/jem.146.4.1164.
Abstract
A resistance locus to leukemogenesis in mice by A-RadLV (a variant of the radiation leukemia virus) is described. This locus, Rrv-1, was mapped to subregions I-A, I-B, and I-J of the H-2 complex. It is suggested that Rrv-1 may be in complementation with a second locus to the right of it, between Rrv-1 and H-2D. This localization and the complementation of the two loci for resistance are characteristics similar to Ir genes, and indicate a possible relationship between the genetic regulation of immune responsiveness and susceptibility to leukemia.
摘要
描述了小鼠中对A-RadLV（辐射白血病病毒的一种变体）致白血病作用的一个抗性位点。该位点Rrv-1被定位到H-2复合体的I-A、I-B和I-J亚区。有人提出，Rrv-1可能与其右侧位于Rrv-1和H-2D之间的第二个位点互补。这两个位点在抗性方面的这种定位和互补是与Ir基因相似的特征，表明免疫反应性的遗传调控与白血病易感性之间可能存在关联。
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