一个新的I亚区（I-J），由一个控制抑制性T淋巴细胞表面决定簇的基因座（Ia-4）标记。
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.
作者信息
Murphy D B, Herzenberg L A, Okumura K, Herzenberg L A, McDevitt H O
出版信息
J Exp Med. 1976 Sep 1;144(3):699-712. doi: 10.1084/jem.144.3.699.
Abstract
In an accompanying publication we show that a subpopulation of T lymphocytes, which includes allotype suppressor T cells, selectively expresses I-region determinants. In this report, we show that these determinants are controlled by a new locus, Ia-4. Unlike the classically defined Ia antigens, they are not found on B lymphocytes. Antibody against Ia-4 determinants cannot be detected by conventional dye exclusion cytoxicity assays, suggesting that they are present on a small subpopulation (less than 10%) of peripheral T lymphocytes. The Ia-4 locus marks a new I subregion, provisionally designated I-J. This chromosomal segment is defined by the crossover positions in strains B10.A(5R) (K-end boundary) and B10.HTT (D-end boundary), and maps between the I-B and I-C subregions.
摘要
在一篇随附的论文中，我们表明T淋巴细胞的一个亚群，包括同种异型抑制性T细胞，选择性地表达I区决定簇。在本报告中，我们表明这些决定簇受一个新的基因座Ia-4控制。与经典定义的Ia抗原不同，它们在B淋巴细胞上未被发现。针对Ia-4决定簇的抗体不能通过传统的染料排除细胞毒性试验检测到，这表明它们存在于外周T淋巴细胞的一个小亚群（少于10%）上。Ia-4基因座标记了一个新的I亚区，暂定为I-J。这个染色体片段由B10.A(5R)株（K端边界）和B10.HTT株（D端边界）中的交叉位置定义，并定位在I-B和I-C亚区之间。
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