The National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and The University of Sydney, Australia.
Epidemiol Infect. 2010 Mar;138(3):426-33. doi: 10.1017/S0950268809990707. Epub 2009 Sep 1.
Comparing pertussis epidemiology over time and between countries is confounded by differences in diagnostic and notification practices. Standardized serological methods applied to population-based samples enhance comparability. Population prevalence of different levels of pertussis toxin IgG (PT IgG) antibody, measured by standardized methods, were compared by age group and region of Australia between 1997/1998 and 2002. The proportion of 5- to 9-year-olds with presumptive recent pertussis infection (based on IgG levels >or=62.5 ELISA units/ml) significantly decreased in 2002, consistent with notification data for the same period and improved uptake of booster vaccines following the schedule change from whole-cell to acellular vaccine. In contrast, recent presumptive infection significantly increased in adults aged 35-49 years. Population-based serosurveillance using standardized PT IgG antibody assays has the potential to aid interpretation of trends in pertussis incidence in relation to vaccine programmes and between countries.
比较随时间推移和国家间的百日咳流行病学情况，由于诊断和报告实践方面的差异而变得复杂。应用于基于人群的样本的标准化血清学方法可提高可比性。通过标准化方法测量，比较了澳大利亚不同地区和年龄组在 1997/1998 年至 2002 年间不同水平的百日咳毒素 IgG（PT IgG）抗体的人群流行率。2002 年，5 至 9 岁儿童中疑似近期百日咳感染（基于 IgG 水平>或=62.5 ELISA 单位/ml）的比例显著下降，这与同期的报告数据一致，并且在全细胞疫苗向无细胞疫苗接种时间表更改后，加强疫苗的接种率提高。相比之下，35-49 岁成人中的近期疑似感染则显著增加。使用标准化的 PT IgG 抗体检测进行基于人群的血清学监测，有可能有助于解释与疫苗接种计划和国家之间的百日咳发病率趋势的关系。
