Collier Sarah M, Moffett Peter
Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA.
Trends Plant Sci. 2009 Oct;14(10):521-9. doi: 10.1016/j.tplants.2009.08.001. Epub 2009 Aug 31.
Plant genomes encode large numbers of highly variable nucleotide binding leucine-rich repeat (NB-LRR) disease resistance proteins. These proteins have been studied extensively to understand their evolution and the molecular basis of their function. Multiple studies indicate that the C-terminal LRR domain plays a pivotal role in defining pathogen recognition specificity. However, a growing body of evidence suggests that the N-termini of NB-LRR proteins also function in pathogen recognition. To formulate a framework that can explain the underlying principles governing NB-LRR function while accommodating findings from different experimental systems, we present a "bait and switch" model. This model proposes a two-step recognition process involving interactions with both cellular cofactors (bait) and the LRR domain, which in turn activates the molecular switch leading to disease resistance.
植物基因组编码大量高度可变的核苷酸结合富含亮氨酸重复序列（NB-LRR）抗病蛋白。人们对这些蛋白进行了广泛研究，以了解它们的进化及其功能的分子基础。多项研究表明，C末端LRR结构域在定义病原体识别特异性方面起关键作用。然而，越来越多的证据表明，NB-LRR蛋白的N末端在病原体识别中也发挥作用。为了构建一个能够解释支配NB-LRR功能的潜在原理同时兼顾来自不同实验系统的研究结果的框架，我们提出了一个“诱饵与转换”模型。该模型提出了一个两步识别过程，涉及与细胞辅助因子（诱饵）和LRR结构域的相互作用，进而激活导致抗病性的分子开关。
