Innok Phongsak, Rukachaisirikul Thitima, Suksamrarn Apichart
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Thailand.
Chem Pharm Bull (Tokyo). 2009 Sep;57(9):993-6. doi: 10.1248/cpb.57.993.
Three new isomeric flavanones, fuscaflavanones A(1) (1), A(2) (2) and B (3), together with six known flavanones, lupinifolin (4), lonchocarpol A (5), a mixture of lonchocarpols C(1) and C(2) (6a, b), and a mixture of lonchocarpols D(1) and D(2) (7a, b), five pterocarpans, sandwicensin (8), phaseollidin (9), erythrabissin I (10), and a mixture of dolichins A and B (11a, b), one chalcone, isobavachalcone (12), and one isoflavone, wighteone (13), were isolated from the bark of Erythrina fusca LOUR. Their structures were elucidated on the basis of spectroscopic data. Some isolates were tested for antiplasmodial and cytotoxic activities and it was found that 5 and 9 exhibited moderate antiplasmodial activity against Plasmodium falciparum. For cytotoxicity, compounds 1, 4, 5, 9 and 12 showed moderate to weak activity against KB, BC and NCI-H187 cells, whereas 2 exhibited only weak activity against KB cells.
从刺桐（Erythrina fusca LOUR.）树皮中分离得到三种新的异构黄烷酮，即暗黄烷酮A(1)（1）、A(2)（2）和B（3），以及六种已知黄烷酮，羽扇豆叶黄酮（4）、隆乔卡波酚A（5）、隆乔卡波酚C(1)和C(2)的混合物（6a，b）、隆乔卡波酚D(1)和D(2)的混合物（7a，b），五种紫檀素，桑德维辛（8）、菜豆蝶啶（9）、刺桐双荚豆素I（10）、多利钦A和B的混合物（11a，b），一种查尔酮，异补骨脂查尔酮（12），以及一种异黄酮，维特酮（13）。根据光谱数据阐明了它们的结构。对部分分离物进行了抗疟和细胞毒性活性测试，发现5和9对恶性疟原虫表现出中等抗疟活性。对于细胞毒性，化合物1、4、5、9和12对KB、BC和NCI-H187细胞表现出中等至弱活性，而2仅对KB细胞表现出弱活性。
