Knapp Małgorzata, Baranowski Marcin, Czarnowski Dariusz, Lisowska Anna, Zabielski Piotr, Górski Jan, Musiał Włodzimierz
Department of Cardiology, Medical University of Białystok, Białystok, Poland.
Med Sci Monit. 2009 Sep;15(9):CR490-3.
The sphingolipid sphingosine-1-phosphate (S1P) plays an important role in protecting the heart against ischemia-reperfusion injury. S1P is normally present in human plasma. However, there are no data available on the effect of myocardial infarction on the plasma concentrations of S1P and related sphingolipids. The aim of this study was to examine the concentrations of S1P, sphinganine-1-phosphate, free sphingosine, free sphinganine, and ceramide in the plasma of patients after myocardial infarction.
MATERIAL/METHODS: The study was performed on two groups of male subjects: controls with no specific complaints (n=21) and patients who had had acute myocardial infarction (n=22). In the latter group, blood was taken immediately after admission to the hospital and five days later. The concentrations of the above compounds were measured by high-pressure liquid chromatography.
The concentrations of S1P and sphinganine-1-phosphate were reduced by ca. 50% both early after infarction and five days later. The concentrations of the other compounds were not affected by myocardial infarction.
The reduction in plasma concentration of S1P after infarction could lessen its protective action on cardiomyocyte viability. The observed reduction in S1P level might be associated with the standard antiplatelet treatment given to patients since thrombocytes are one of the major sources of plasma S1P.
鞘脂类物质鞘氨醇-1-磷酸（S1P）在保护心脏免受缺血再灌注损伤方面发挥着重要作用。S1P通常存在于人体血浆中。然而，关于心肌梗死对血浆中S1P及相关鞘脂类物质浓度的影响尚无相关数据。本研究的目的是检测心肌梗死后患者血浆中S1P、鞘氨醇-1-磷酸、游离鞘氨醇、游离鞘氨醇胺和神经酰胺的浓度。
材料/方法：本研究对两组男性受试者进行：无特殊主诉的对照组（n = 21）和急性心肌梗死患者组（n = 22）。在后一组中，患者入院后立即及五天后采集血液。上述化合物的浓度通过高压液相色谱法测定。
梗死早期及五天后，S1P和鞘氨醇-1-磷酸的浓度均降低了约50%。其他化合物的浓度不受心肌梗死的影响。
梗死后血浆中S1P浓度的降低可能会减弱其对心肌细胞活力的保护作用。观察到的S1P水平降低可能与给予患者的标准抗血小板治疗有关，因为血小板是血浆S1P的主要来源之一。
