Wright P F, Hatch M H, Kasselberg A G, Lowry S P, Wadlington W B, Karzon D T
J Pediatr. 1977 Sep;91(3):408-12. doi: 10.1016/s0022-3476(77)81309-7.
Paralytic poliomyelitis was observed in a child with a sex-linked defect in immunoglobulin synthesis. Evidence is presented that this was secondary to administration of oral, live poliovaccine. The demonstration of a familial sex-linked gammaglobulin deficiency and the failure to document a defect in cell-mediated immunity in this child extends the risk of vaccine associated poliomyelitis to virtually all forms of immunodeficiency. The critical host factors in the pathogenesis of poliovirus vaccine infection and in particular its unfavorable outcome appear to include either a deficiency in the humoral (B cell) system or in the cell-mediated (T cell) system.
在一名患有免疫球蛋白合成性连锁缺陷的儿童中观察到麻痹性脊髓灰质炎。有证据表明，这是口服减毒活脊髓灰质炎疫苗所致的继发性病变。该儿童存在家族性性连锁γ球蛋白缺乏症，且未证明其细胞介导免疫存在缺陷，这表明疫苗相关性脊髓灰质炎的风险实际上扩展至所有形式的免疫缺陷。脊髓灰质炎病毒疫苗感染发病机制中的关键宿主因素，尤其是其不良后果，似乎包括体液（B细胞）系统或细胞介导（T细胞）系统的缺陷。
