Ballow Mark
Division of Allergy/Clinical Immunology, Department of Pediatrics, Women & Children's Hospital of Buffalo, SUNY Buffalo School of Medicine and Biomedical Sciences, 219 Bryant Street, Buffalo, NY 14222, USA.
Clin Rev Allergy Immunol. 2008 Apr;34(2):129-40. doi: 10.1007/s12016-007-8041-2.
Children with a history of recurrent or unusual infections present a diagnostic challenge. Differentiation between frequent infections caused by common risk factors, versus primary immune dysfunction should be based on a detailed history and physical examination and, if indicated, followed by appropriate laboratory studies. A high index of suspicion could lead to an early diagnosis and treatment of an underlying immune deficiency disease. This article presents to physicians an approach to the evaluation of children with recurrent infections. Important details from the history and physical examination, and an appropriate choice of screening laboratory test to be ordered in a given situation are discussed.
有反复感染或特殊感染病史的儿童面临诊断挑战。区分由常见风险因素引起的频繁感染与原发性免疫功能障碍，应基于详细的病史和体格检查，并在必要时进行适当的实验室检查。高度怀疑可能会导致对潜在免疫缺陷疾病的早期诊断和治疗。本文向医生介绍了一种评估反复感染儿童的方法。文中讨论了病史和体格检查的重要细节，以及在特定情况下应选择的合适筛查实验室检查。
