Scorza Fulvio A, Arida Ricardo M, Naffah-Mazzacoratti Maria da Graça, Scerni Débora A, Calderazzo Lineu, Cavalheiro Esper A
Disciplina de Neurologia Experimental, Universidade Federal de São Paulo/Escola Paulista de Medicina, Rua Botucatu, 862, Edifício José Leal Prado, 04023-900 São Paulo, SP, Brasil.
An Acad Bras Cienc. 2009 Sep;81(3):345-65. doi: 10.1590/s0001-37652009000300003.
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.
在大鼠中全身给予强效毒蕈碱激动剂毛果芸香碱会引发一系列行为和脑电图变化，这些变化可分为3个不同阶段：(a) 急性期，逐渐发展为边缘性癫痫持续状态，持续24小时；(b) 静止期，脑电图和行为逐渐恢复正常，持续时间为4至44天；(c) 慢性期，出现自发性反复癫痫发作（SRSs）。长期观察到的SRSs的主要特征类似于人类复杂部分性癫痫发作，每只动物每周发作2至3次。因此，毛果芸香碱癫痫模型不仅是研究人类颞叶癫痫发病机制的宝贵工具，也是评估潜在抗癫痫药物的重要手段。本综述重点关注毛果芸香碱癫痫模型的数据。
