Cavalheiro E A, Santos N F, Priel M R
Neurologia Experimental, UNIFESP-EPM, São Paulo, Brasil.
Epilepsia. 1996 Oct;37(10):1015-9. doi: 10.1111/j.1528-1157.1996.tb00541.x.
To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.
After status epilepticus, the surviving animals were continuously monitored for 24 h/day for < or = 120 days. The brains were processed by using neo-Timm and Nissl stains.
The first spontaneous seizures occurred between 4 and 42 days after status epilepticus. The mean "seizure-silent period" lasted for 14.4 +/- 11.9 days. During the chronic phase, recurrent spontaneous seizures were observed 1-5 times per animal per week and were associated with sprouting in the supragranular layer of the dentate gyrus.
Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice.
描述匹鲁卡品诱导小鼠持续性癫痫发作的急性和慢性行为、脑电图及组织学效应。
癫痫持续状态后，对存活动物每天24小时持续监测≤120天。采用新Timm染色和尼氏染色处理大脑。
首次自发性癫痫发作发生在癫痫持续状态后4至42天之间。平均“癫痫发作静止期”持续14.4±11.9天。在慢性期，每只动物每周观察到1至5次复发性自发性癫痫发作，且与齿状回颗粒上层的发芽有关。
匹鲁卡品诱导的癫痫持续状态所促进的脑结构损伤可能是小鼠复发性自发性癫痫发作的基础或与之相关。
