Patterson Katherine, Young Corinna, Woods Steven Paul, Vigil Ofilio, Grant Igor, Atkinson J Hampton
Department of Psychiatry, University of California-San Diego, 150 West Washington Street, San Diego, CA 92103, USA.
Int J Methods Psychiatr Res. 2006 Jun;15(2):75-82. doi: 10.1002/mpr.184.
Major Depressive Disorder (MDD) is among the most prevalent but underdiagnosed psychiatric disorders in persons with HIV infection. Given the known adverse impact of comorbid MDD on HIV disease progression and health-related quality of life, it is important both for research and for efficient, effective clinical care, to validate existing screening measures that may discriminate between MDD and the somatic symptoms of HIV (such as fatigue). In the current study, we evaluated the concurrent predictive validity of the Profile of Mood States (POMS) Depression-Dejection scale in detecting current MDD in 310 persons with HIV infection. The Structured Clinical Interview for DSM-IV (SCID) diagnosis of MDD and the Cognitive-Affective scale from the Beck Depression Inventory (BDI-CA) served as comparative diagnostic and severity measures of depression, respectively. Results demonstrated that the POMS Depression-Dejection scale accurately classified persons with and without MDD SCID diagnoses, with an overall hit rate of 80%, sensitivity of 55%, specificity of 84%, and negative predictive power of 91% using a recommended cutpoint of 1.5 standard deviations above the normative mean. Moreover, the POMS performed comparably to the BDI-CA in classifying MDD. Findings support the predictive validity of the POMS Depression-Dejection scale as a screening instrument for MDD in persons with HIV disease.
重度抑郁症（MDD）是艾滋病毒感染者中最常见但诊断不足的精神疾病之一。鉴于合并MDD对艾滋病毒疾病进展和健康相关生活质量的已知不利影响，对于研究以及高效、有效的临床护理而言，验证现有的可能区分MDD和艾滋病毒躯体症状（如疲劳）的筛查措施非常重要。在当前研究中，我们评估了情绪状态剖面图（POMS）抑郁-沮丧量表在检测310名艾滋病毒感染者当前MDD方面的同时预测效度。《精神疾病诊断与统计手册》第四版（DSM-IV）的MDD结构化临床访谈以及贝克抑郁量表（BDI-CA）的认知-情感量表分别作为抑郁的比较诊断和严重程度测量工具。结果表明，POMS抑郁-沮丧量表能够准确地对有和没有MDD SCID诊断的人进行分类，使用高于常模均值1.5个标准差的推荐切点时，总体命中率为80%，敏感性为55%，特异性为84%，阴性预测能力为91%。此外，POMS在对MDD进行分类时与BDI-CA表现相当。研究结果支持POMS抑郁-沮丧量表作为艾滋病毒疾病患者MDD筛查工具的预测效度。
