Leijonmarck C E, Benno P, Carlstedt-Duke B, Monsen U, Norin E, Poppen B, Saxerholt H, Midtvedt T
Dept. of Surgery, St. Goran's Hospital, Stockholm, Sweden.
Scand J Gastroenterol. 1990 Jun;25(6):585-93. doi: 10.3109/00365529009095534.
The function of the intestinal microflora was studied in patients with ulcerative colitis before and after colectomy. The following six microflora-associated characteristics (MACs) were investigated: formation of coprostanol and urobilinogen; degradation of mucin, water-soluble protein, and beta-aspartylglycine; and presence of faecal tryptic activity. In 12 unoperated patients without sulphasalazine as maintenance therapy the six MACs were similar to those in normal subjects. In 12 unoperated patients receiving sulphasalazine the formation of coprostanol and urobilinogen was significantly lower (p less than 0.01 and p less than 0.001, respectively) and the level of faecal tryptic activity was significantly higher (p less than 0.01) than in normal subjects. The functional capacity of the microflora in operated patients treated by colectomy combined with one of four surgical procedures (ileorectal anastomosis, ileoanal anastomosis with pelvic pouch, Kock's continent ileostomy, or conventional ileostomy) was disturbed with regard to all six MACs. The disturbance was most pronounced in patients with conventional ileostomy.
对溃疡性结肠炎患者在结肠切除术前和术后的肠道微生物群功能进行了研究。研究了以下六个与微生物群相关的特征（MACs）：粪甾烷醇和尿胆原的形成；粘蛋白、水溶性蛋白质和β-天冬氨酰甘氨酸的降解；以及粪便胰蛋白酶活性的存在。在12例未接受柳氮磺胺吡啶维持治疗的未手术患者中，这六个MACs与正常受试者相似。在12例接受柳氮磺胺吡啶治疗的未手术患者中，粪甾烷醇和尿胆原的形成显著降低（分别为p<0.01和p<0.001），粪便胰蛋白酶活性水平显著高于正常受试者（p<0.01）。接受结肠切除术并结合四种手术方式之一（回肠直肠吻合术、带盆腔袋的回肠肛管吻合术、科克可控回肠造口术或传统回肠造口术）治疗的手术患者，其微生物群的功能能力在所有六个MACs方面均受到干扰。这种干扰在传统回肠造口术患者中最为明显。
