Benno P, Leijonmarck C E, Monsén U, Uribe A, Midtvedt T
Dept. of Medicine, Danderyd Hospital, Sweden.
Scand J Gastroenterol. 1993 Sep;28(9):839-44. doi: 10.3109/00365529309104019.
The aim of the study was to examine microflora-associated characteristics in patients with inactive ulcerative colitis, receiving sulphasalazine, in relation to the spread of the disease. The conversion of cholesterol to coprostanol, the production of urobilinogen, and the degradation of tryptic activity (FTA) and beta-aspartylglycine were measured in faecal samples from patients with proctitis or left-sided or total ulcerative colitis and in age- and sex-matched controls. No significant differences in the results were observed in patients with various degrees of extension of inflammatory bowel disease. However, the coprostanol ratio and the urobilinogen level were lower and the FTA was higher in patients with colitis than in the controls (p < 0.05). Beta-aspartylglycine was not found in any faecal sample. The results indicate that patients with ulcerative colitis taking sulphasalazine have a microflora with abnormal metabolic characteristics.
本研究的目的是检查接受柳氮磺胺吡啶治疗的非活动性溃疡性结肠炎患者的微生物群相关特征与疾病传播的关系。在直肠炎、左侧或全溃疡性结肠炎患者以及年龄和性别匹配的对照者的粪便样本中，测量了胆固醇向粪甾烷醇的转化、尿胆原的产生以及胰蛋白酶活性（FTA）和β-天冬氨酰甘氨酸的降解。在炎症性肠病不同程度扩展的患者中，未观察到结果有显著差异。然而，结肠炎患者的粪甾烷醇比率和尿胆原水平较低，FTA较高（p<0.05）。在任何粪便样本中均未发现β-天冬氨酰甘氨酸。结果表明，服用柳氮磺胺吡啶的溃疡性结肠炎患者的微生物群具有异常的代谢特征。
