Schaefer Sydney Y, Haaland Kathleen Y, Sainburg Robert L
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.
Brain Res. 2009 Nov 17;1298:78-91. doi: 10.1016/j.brainres.2009.08.063. Epub 2009 Sep 1.
Previous studies have demonstrated that following stroke, motor impairment can occur ipsilateral to the lesion. Such impairments have provided insight into the contributions of each hemisphere to movement control, showing that left and right hemisphere damage produce different effects on movement: Left hemisphere damage produces deficits in specifying features of movement trajectory, while right hemisphere damage produces deficits in achieving an accurate and stable final position. We now propose that left and right hemisphere damage should also produce different deficits in the adaptation of trajectory and position. To test this idea, we examined adaptation to visuomotor rotations in the ipsilesional arms of hemiparetic stroke patients with left (LHD) and right hemisphere damage (RHD). We found that LHD interfered with adaptation of initial direction, but not with the ability to adapt the final position of the limb. In contrast, RHD interfered with online corrections to the final position during the course of adaptation. These findings support our hypothesis that the control of trajectory and steady-state position may be lateralized to the left and right hemispheres, respectively.
先前的研究表明，中风后，运动障碍可能出现在病灶同侧。这些障碍为了解每个半球对运动控制的贡献提供了线索，表明左半球和右半球损伤对运动产生不同的影响：左半球损伤会导致在确定运动轨迹特征方面出现缺陷，而右半球损伤会导致在实现准确和稳定的最终位置方面出现缺陷。我们现在提出，左半球和右半球损伤在轨迹和位置适应方面也应产生不同的缺陷。为了验证这一想法，我们研究了左半球损伤（LHD）和右半球损伤（RHD）的偏瘫中风患者患侧手臂对视觉运动旋转的适应情况。我们发现，左半球损伤会干扰初始方向的适应，但不影响肢体最终位置的适应能力。相比之下，右半球损伤会干扰适应过程中对最终位置的在线校正。这些发现支持了我们的假设，即轨迹控制和稳态位置控制可能分别定位于左半球和右半球。
