Sonne M P, Højbjerre L, Alibegovic A C, Vaag A, Stallknecht B, Dela F
Department of Biomedical Sciences, Section of Systems Biology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
J Vasc Res. 2010;47(2):139-47. doi: 10.1159/000235968. Epub 2009 Sep 4.
Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22).
Insulin sensitivity and endothelial function was studied with venous occlusion plethysmography and intra-arterial infusions of adenosine and acetylcholine, before and during a hyperinsulinemic isoglycemic clamp.
Forearm blood flow response to systemic hyperinsulinemia was diminished in LBW compared to controls (p < 0.05). Fractional arteriovenous glucose extraction was similar, and consequently insulin-stimulated forearm glucose clearance was diminished in LBW compared with controls (0.8 +/- 0.09 vs. 1.4 +/- 0.36 ml x 100 ml(-1) x min(-1), respectively, p < 0.05). Forearm blood flow response to adenosine and acetylcholine with or without insulin stimulation did not differ between groups. Whole-body glucose uptake was lower in LBW than controls (8.7 +/- 0.5 and 9.1 +/- 0.6 mg x min(-1) x kg(-1) lean body mass); however, this was not significant.
Forearm blood flow response to insulin is impaired in LBW, whereas the response to adenosine and acetylcholine is preserved. The impaired insulin-mediated increase in bulk flow in LBW may be due to an impairment of insulin-mediated capillary recruitment independent of - or preceding - whole-body insulin resistance in LBW subjects.
低出生体重（LBW）与2型糖尿病和心血管疾病风险增加相关。我们研究了低出生体重男性（n = 22）和对照组（n = 22）的内皮功能和胰岛素敏感性。
在高胰岛素正常血糖钳夹试验之前及期间，采用静脉闭塞体积描记法以及动脉内输注腺苷和乙酰胆碱的方法，研究胰岛素敏感性和内皮功能。
与对照组相比，低出生体重组对全身性高胰岛素血症的前臂血流反应减弱（p < 0.05）。动静脉葡萄糖摄取分数相似，因此与对照组相比，低出生体重组胰岛素刺激的前臂葡萄糖清除率降低（分别为0.8 ± 0.09与1.4 ± 0.36 ml×100 ml⁻¹×min⁻¹，p < 0.05）。两组之间，无论有无胰岛素刺激，对腺苷和乙酰胆碱的前臂血流反应均无差异。低出生体重组的全身葡萄糖摄取低于对照组（8.7 ± 0.5和9.1 ± 0.6 mg×min⁻¹×kg⁻¹去脂体重）；然而，这并无统计学意义。
低出生体重组对胰岛素的前臂血流反应受损，而对腺苷和乙酰胆碱的反应则保持正常。低出生体重组胰岛素介导的总体血流增加受损可能是由于胰岛素介导的毛细血管募集受损，这独立于或先于低出生体重个体的全身胰岛素抵抗。
