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Animal models of spondyloarthritis.

作者信息

Taurog Joel D

机构信息

Rheumatic Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8884, USA.

出版信息

Adv Exp Med Biol. 2009;649:245-54. doi: 10.1007/978-1-4419-0298-6_18.

DOI:10.1007/978-1-4419-0298-6_18
PMID:19731634
Abstract

Animal models are available for the study of several different aspects of spondyloarthritis. The models include naturally occurring spontaneous disorders in primates and rodents, spontaneous disorders in transgenic or gene-deleted rodents and induced disorders in rodents. Areas of investigation to which these models contribute include the role HLA-B27, processes of spinal and peripheral joint inflammation and calcification, immune responses to candidate antigens and the role of TNF.

摘要

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