苏丹 31 例疑似先天性风疹综合征婴儿的初步调查。

Primary investigation of 31 infants with suspected congenital rubella syndrome in Sudan.

机构信息

Commission for Biotechnology and Genetic Engineering - National Centre for Research - Ministry of Science and Technology, Health Protection Agency, London, UK.

出版信息

Clin Microbiol Infect. 2010 Jun;16(6):678-82. doi: 10.1111/j.1469-0691.2009.02966.x. Epub 2009 Sep 2.

DOI:10.1111/j.1469-0691.2009.02966.x

PMID:19732080

Abstract

Between 2005 and 2006, clinical specimens were collected from 31 infants with suspected congenital rubella syndrome (CRS) who presented at six hospitals in Khartoum, Sudan. Eleven (35.5%) were laboratory confirmed as CRS cases by testing for anti-rubella IgM, IgG and viral genome. For the first time in Sudan, the rubella virus genome was directly detected in clinical specimens of six CRS cases and two viruses were isolated in cell culture. Phylogenetic analysis suggested that three genotypes of rubella virus (RV; 1E, 2B and 1G) were co-circulating in Sudan. The study introduced the methodology for CRS confirmation and surveillance in Sudan and provides preliminary data.

摘要

2005 年至 2006 年期间，从苏丹喀土穆六家医院就诊的 31 名疑似先天性风疹综合征（CRS）婴儿采集了临床标本。通过检测抗风疹 IgM、IgG 和病毒基因组，11 例（35.5%）被实验室确认为 CRS 病例。这是风疹病毒基因组首次在苏丹 CRS 病例的临床标本中直接检测到，两种病毒在细胞培养中分离。系统进化分析表明，三种基因型的风疹病毒（RV；1E、2B 和 1G）在苏丹同时流行。该研究介绍了在苏丹进行 CRS 确认和监测的方法，并提供了初步数据。