Lönnroth I, Holmgren J, Lange S
Med Biol. 1977 Jun;55(3):126-9.
The effect of chlorpromazine on cholera-toxin-induced intestinal fluid secretion (experimental cholera) has been tested in vivo in the mouse. It is shown that intramuscular injection of chlorpromazine 1 hr prior to toxin challenge effectively inhibits the net secretory response of the intestine. It is suggested that this effect might be due to inhibition of adenylate cyclase since chlorpromazine inhibits the increase of cyclic AMP concentration in vitro in mouse thymocytes incubated with cholera toxin.
已在小鼠体内测试了氯丙嗪对霍乱毒素诱导的肠液分泌(实验性霍乱)的影响。结果表明,在毒素攻击前1小时肌肉注射氯丙嗪可有效抑制肠道的净分泌反应。有人提出,这种作用可能是由于抑制了腺苷酸环化酶,因为氯丙嗪在体外可抑制与霍乱毒素一起孵育的小鼠胸腺细胞中环状AMP浓度的升高。