Warkentin S, Nilsson A, Risberg J, Karlson S, Flekköy K, Franzén G, Gustafson L, Rodriguez G
Department of Psychogeriatrics, CBF-Lab, St. Lars Hospital, Lund, Sweden.
Psychiatry Res. 1990 Apr;35(1):27-38. doi: 10.1016/0925-4927(90)90006-r.
Regional cerebral blood flow (rCBF) measurements and clinical ratings were performed on 17 schizophrenic patients and a subgroup of 10 medication-free patients before and after treatment. While clinically exacerbated patients had normal blood flow, patients in remission showed a redistribution of flow with lower values in frontal areas. Anteroposterior ratios correlated with the degree of behavioral disturbances, suggesting that the level of frontal lobe activity in schizophrenia may be a function of the patient's clinical state at the time of study.
