Stefan H
University Hospital Erlangen, Epilepsy Center - Neurological Clinic, Germany.
Rev Neurol (Paris). 2009 Oct;165(10):742-5. doi: 10.1016/j.neurol.2009.07.014. Epub 2009 Sep 5.
Epilepsy surgery primarily aims to control seizures in cases of drug-resistant epilepsy; in addition, neurological or neuropsychological deficits need to be avoided, and social integration improved. Determination of the specific site and extent of interictal and ictal epileptic brain regions is the main task of the presurgical evaluation of partial epilepsies. An additional challenge of the preoperative work-up is to delineate the functionally important regions (motor, somatosensory, language). As a new, non-invasive, functional modality, magnetoencephalography (MEG) yields information that is complementary to electroencephalography (EEG) and magnetic resonance imaging (MRI). As magnetic field distortion by the brain, cerebrospinal fluid, skull and skin is negligible, the technique offers a virtually undistorted view of brain activity and, thus, offers excellent spatiotemporal resolution. In general, MEG is used for focus localization as well as functional mapping as part of the clinical routine. This report presents an overview of the technique, as well as its advantages and limitations in the clinical context of epileptology.
癫痫手术主要旨在控制药物难治性癫痫患者的癫痫发作；此外，还需避免神经或神经心理缺陷，并改善社会融合情况。确定发作间期和发作期癫痫脑区的具体部位及范围是部分癫痫术前评估的主要任务。术前检查的另一项挑战是描绘功能重要区域（运动、躯体感觉、语言）。作为一种新型的非侵入性功能检查方法，脑磁图（MEG）可提供与脑电图（EEG）和磁共振成像（MRI）互补的信息。由于大脑、脑脊液、颅骨和皮肤对磁场的扭曲可忽略不计，该技术能提供几乎未受扭曲的脑活动视图，因此具有出色的时空分辨率。一般而言，MEG作为临床常规检查的一部分，用于病灶定位及功能图谱绘制。本报告概述了该技术及其在癫痫学临床应用中的优势与局限性。
