Pleass Richard J, Behnke Jerzy M
Institute of Genetics, and Parasite Biology and Immunogenetics Research Group, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK.
Trends Parasitol. 2009 Oct;25(10):443-6. doi: 10.1016/j.pt.2009.07.001. Epub 2009 Sep 4.
Two recent papers published in Immunity and Cell Host & Microbe underline the great importance of B cells and of antibodies (Abs) in orchestrating crucial T helper cell type 2 (Th2) protective immune responses to gastrointestinal nematodes. The findings in animal models now raise major questions as to how B cells and Abs carry out these functions in humans. Here we discuss recent technological advances in humanizing animal models at the level of both Abs and their Fc-receptors, that might provide some answers.
最近发表在《免疫》和《细胞宿主与微生物》上的两篇论文强调了B细胞和抗体（Abs）在协调对胃肠道线虫的关键2型辅助性T细胞（Th2）保护性免疫反应中的重要性。动物模型中的这些发现现在引发了关于B细胞和抗体如何在人类中执行这些功能的重大问题。在此，我们讨论了在抗体及其Fc受体水平上使动物模型人源化的最新技术进展，这些进展可能会提供一些答案。
