Singh Vineeta, Mishra Neelima, Awasthi Gauri, Dash Aditya P, Das Aparup
National Institute of Malaria Research, Sector 8, Dwarka, New Delhi 110077, India.
Trends Parasitol. 2009 Oct;25(10):452-7. doi: 10.1016/j.pt.2009.06.004. Epub 2009 Sep 4.
Malaria is a major vector-borne disease in India. Based on vast geographic areas with associated topographic and climatic diversity, the variable malaria epidemiology in India is associated with high parasite genetic diversity and rapidly evolving drug resistance, differential distribution of vector species and emerging insecticide resistance and underlying human genetic diversity and past evolutionary histories. Further, changing climatic patterns have possibly changed malaria epidemiology to a great extent. The outcome of these changes is an increased incidence of Plasmodium falciparum over the P. vivax malaria in recent years. Accordingly, the drug and insecticide application policy in India has changed too. The above facts and associated rapid shifting trend of malaria epidemiology makes India a hot-spot for malaria research.
疟疾是印度一种主要的媒介传播疾病。基于具有相关地形和气候多样性的广阔地理区域，印度多变的疟疾流行病学与高寄生虫遗传多样性、迅速演变的耐药性、媒介物种的差异分布和新出现的杀虫剂抗性以及潜在的人类遗传多样性和过去的进化史有关。此外，不断变化的气候模式可能在很大程度上改变了疟疾流行病学。这些变化的结果是近年来恶性疟原虫的发病率高于间日疟原虫。因此，印度的药物和杀虫剂应用政策也发生了变化。上述事实以及疟疾流行病学相关的快速变化趋势使印度成为疟疾研究的热点地区。
