Nishimura Keiichiro, Hatanaka Shogo, Utsumi Nobuko, Yamano Takafumi, Shimbo Munefumi, Takahashi Takeo
Department of Radiation Oncology, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.
Department of Radiation Therapy, JCHO Tokyo Shinjuku Medical Center, Tokyo, JPN.
Cureus. 2021 Sep 5;13(9):e17743. doi: 10.7759/cureus.17743. eCollection 2021 Sep.
Aim To investigate the variation of tumor volume during moderate hypo-fractionated stereotactic body radiation therapy (SBRT). Patients and Methods Twenty patients, who received SBRT at our institution, were included in the analysis. A prescribed dose was 56 Gy at iso-center in seven fractions. Tumor volumes before and during SBRT were calculated. In order to investigate factors affecting the variation of tumor volume in RT 2 (after first irradiation) and RT 7 (after last irradiation), various parameters were verified by the Mann-Whitney test. Results With regard to the low maximum standardized uptake values (SUVmax) group, transient increase of tumor volume was found in RT 2, and tumor volume reduction was hardly found in RT 7. With regard to the high SUVmax group, a transient increase was not found, and a definite reduction was found in the treatment course. Conclusion Accurate prediction of tumor volume variation is required for more accurate treatment, such as adaptive radiation therapy.
目的 探讨中等分割立体定向体部放射治疗（SBRT）期间肿瘤体积的变化。患者与方法 分析在本机构接受SBRT的20例患者。等中心处方剂量为56 Gy，分7次照射。计算SBRT前及治疗期间的肿瘤体积。为研究影响放疗第2次（首次照射后）和第7次（末次照射后）肿瘤体积变化的因素，采用Mann-Whitney检验验证各项参数。结果 低最大标准化摄取值（SUVmax）组在放疗第2次时肿瘤体积出现短暂增大，在放疗第7次时几乎未发现肿瘤体积缩小。高SUVmax组未出现短暂增大，在治疗过程中发现肿瘤体积有明确缩小。结论 为实现更精确的治疗，如自适应放射治疗，则需要准确预测肿瘤体积变化。
