Institute of Clinical Medicine, Department of Pediatrics, Biocenter Oulu, University of Oulu, FIN-90014, Oulu, Finland.
Ann Med. 2009;41(8):629-42. doi: 10.1080/07853890903186176.
Surfactant protein (SP) C has been shown to be expressed also outside pulmonary alveoli. Certain SP-C gene (SFTPC) polymorphisms associate with lung diseases and very preterm birth.
We investigated the association of SFTPC single nucleotide polymorphism (SNP) rs4715 with factors affecting spontaneous preterm birth and characterized the SP-C expression in human and mouse gestational tissues.
The SFTPC SNP rs4715 polymorphism was genotyped in a homogeneous northern European population of mothers and infants in spontaneous preterm birth and term controls. The expression and protein of SP-C in gestational tissues was analyzed.
SFTPC SNP rs4715 did not associate with spontaneous preterm birth. However, fetuses with short interval (<72 hours) between preterm premature rupture of fetal membranes (PPROM) and preterm birth had significant over-representation of the minor allele A, whereas in fetuses with prolonged PPROM (>or=72 hours) the frequency was decreased. Maternal SFTPC did not associate with the duration of PPROM. SP-C mRNA and proprotein were detected in fetal membranes, placenta, and pregnant uterus.
SFTPC SNP rs4715 associates with the duration of PPROM, and SP-C is expressed in gestational tissues. We propose that fetal SFTPC moderates the inflammatory activation within the fetal extra-embryonic compartment.
表面活性蛋白（SP）C 已被证明也在肺肺泡外表达。某些 SP-C 基因（SFTPC）多态性与肺部疾病和极早产有关。
我们研究了 SFTPC 单核苷酸多态性（SNP）rs4715 与影响自发性早产的因素的关联，并对人类和小鼠妊娠组织中的 SP-C 表达进行了特征描述。
在自发性早产和足月对照组的同质北欧人群中，对 SFTPC SNP rs4715 多态性进行了基因分型。分析了妊娠组织中 SP-C 的表达和蛋白。
SFTPC SNP rs4715 与自发性早产无关。然而，在早产胎膜早破（PPROM）和早产之间间隔较短（<72 小时）的胎儿中，次要等位基因 A 的出现频率显著增加，而在 PPROM 时间较长（≥72 小时）的胎儿中，其频率降低。母体 SFTPC 与 PPROM 的持续时间无关。在胎膜、胎盘和妊娠子宫中检测到 SP-C mRNA 和前蛋白。
SFTPC SNP rs4715 与 PPROM 的持续时间有关，SP-C 在妊娠组织中表达。我们提出胎儿 SFTPC 调节胎儿胚胎外隔室的炎症激活。
