Deng Ye, Chin Young-Won, Chai Heebyung, Keller William J, Kinghorn A Douglas
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
J Nat Prod. 2007 Dec;70(12):2049-52. doi: 10.1021/np070501z. Epub 2007 Dec 13.
Two new benzophenones, morintrifolins A ( 1) and B ( 2), together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of Morinda citrifolia roots. Of the isolated compounds, four known anthraquinones, namely, 1,2-dihydroxyanthraquinone ( 3), 1,3-dihydroxy-2-methylanthraquinone ( 4), 2-hydroxy-3-(hydroxymethyl)anthraquinone ( 5), and 1,3,6-trihydroxy-2-methylanthraquinone ( 6), exhibited quinone reductase (QR)- inducing activity in Hepa lclc7 cells, with concentrations required to double QR activity of 12.0, 8.1, 0.94, and 0.56 microM, respectively.
从巴戟天根的氯仿可溶提取物中分离出两种新的二苯甲酮，即巴戟天三醇A（1）和B（2），以及14种已知的蒽醌和其他四种已知化合物。在分离出的化合物中，四种已知的蒽醌，即1,2 - 二羟基蒽醌（3）、1,3 - 二羟基 - 2 - 甲基蒽醌（4）、2 - 羟基 - 3 -（羟甲基）蒽醌（5）和1,3,6 - 三羟基 - 2 - 甲基蒽醌（6），在Hepa lclc7细胞中表现出醌还原酶（QR）诱导活性，使QR活性加倍所需的浓度分别为12.0、8.1、0.94和0.56 microM。
