从椭圆山蚂蝗（Rubiaceae）的根中提取出具有抗疟活性的蒽醌类化合物。
Anthraquinones with antiplasmodial activity from the roots of Rennellia elliptica Korth. (Rubiaceae).
机构信息
Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.
出版信息
Molecules. 2010 Oct 20;15(10):7218-26. doi: 10.3390/molecules15107218.
Dichloromethane root extract of Rennellia elliptica Korth. showed strong inhibition of Plasmodium falciparum growth in vitro with an IC₅₀ value of 4.04 µg/mL. A phytochemical study of the dichloromethane root extract has led to the isolation and characterization of a new anthraquinone, 1,2-dimethoxy-6-methyl-9,10-anthraquinone (1), and ten known anthraquinones: 1-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (2), nordamnacanthal (3), 2-formyl-3-hydroxy-9,10-anthraquinone (4), damnacanthal (5), lucidin-ω-methyl ether (6), 3-hydroxy-2-methyl-9,10-anthraquinone (7), rubiadin (8), 3-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (9), rubiadin-1-methyl ether (10) and 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone (11). Structural elucidation of all compounds was accomplished by modern spectroscopic methods, notably 1D and 2D NMR, IR, UV and HREIMS. The new anthraquinone 1, 2-formyl-3-hydroxy-9,10-anthraquinone (4) and 3-hydroxy-2-methyl-9,10-anthraquinone (7) possess strong antiplasmodial activity, with IC₅₀ values of 1.10, 0.63 and 0.34 µM, respectively.
椭圆楼梯草根的二氯甲烷提取物对体外疟原虫生长表现出强烈的抑制作用，IC₅₀值为 4.04 µg/mL。对二氯甲烷根提取物的植物化学研究导致分离和鉴定了一种新的蒽醌，1,2-二甲氧基-6-甲基-9,10-蒽醌（1）和十种已知的蒽醌：1-羟基-2-甲氧基-6-甲基-9,10-蒽醌（2），诺达玛坎塔尔（3），2-甲酰基-3-羟基-9,10-蒽醌（4），damnacanthal（5），卢西丁-ω-甲醚（6），3-羟基-2-甲基-9,10-蒽醌（7），茜素（8），3-羟基-2-甲氧基-6-甲基-9,10-蒽醌（9），茜素-1-甲醚（10）和 3-羟基-2-羟甲基-9,10-蒽醌（11）。所有化合物的结构鉴定均通过现代光谱方法完成，特别是 1D 和 2D NMR、IR、UV 和 HREIMS。新的蒽醌 1、2-甲酰基-3-羟基-9,10-蒽醌（4）和 3-羟基-2-甲基-9,10-蒽醌（7）具有很强的抗疟原虫活性，IC₅₀值分别为 1.10、0.63 和 0.34 µM。
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