Vasilyev Evgeny V, Trofimov Dmitry Y, Tonevitsky Alexander G, Ilinsky Valery V, Korostin Dmitriy O, Rebrikov Denis V
DNA-Technology JSC, Kashirskoe shosse, 23-5-16, Moscow, 115478, Russia.
Virol J. 2009 Sep 7;6:134. doi: 10.1186/1743-422X-6-134.
Torque teno virus (TTV) is a circular, single-stranded DNA virus that chronically infects healthy individuals of all ages worldwide. There is a lot of data on the prevalence and genetic heterogeneity of TTV in healthy populations and in patients with various diseases now available. However, little is known about TTV load among healthy human population. In this study we analyzed TTV load in the group of 512 Russian elite athletes, who are supposed to be, by some standards, the healthiest part of the human population.
The prevalence rate of TTV among the Russian Olympic Reserve members was 94% (for test sensitivity about 1000 genome equivalents per 1 ml of blood). Quantities varied from 103 (which corresponded to detection limit) to 1010 copies per 1 ml of blood, with median at 2.7 x 106 copies.
About 94% of healthy individuals in Russian population have more than 1000 TTV genome copies per 1 ml of blood. This result exceeds the previously published data, and can be explained by either more sensitive PCR test system or by higher TTV distribution in Russian population or both. TTV viral load neither depends on gender, nor age.
细小病毒B19（TTV）是一种环状单链DNA病毒，可长期感染全球所有年龄段的健康个体。目前已有大量关于健康人群和各类疾病患者中TTV流行率及基因异质性的数据。然而，对于健康人群中的TTV载量了解甚少。在本研究中，我们分析了512名俄罗斯精英运动员群体中的TTV载量，按照某些标准，这些运动员被认为是人群中最健康的一部分。
俄罗斯奥运后备队员中TTV的流行率为94%（检测灵敏度约为每1毫升血液1000个基因组当量）。数量范围从每1毫升血液10³（相当于检测限）到10¹⁰拷贝，中位数为2.7×10⁶拷贝。
俄罗斯人群中约94%的健康个体每1毫升血液中TTV基因组拷贝数超过1000个。这一结果超过了此前发表的数据，可能是由于更灵敏的PCR检测系统，或者是俄罗斯人群中TTV分布更广泛，或者两者兼而有之。TTV病毒载量既不取决于性别，也不取决于年龄。
