Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, Medical College, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, PR China.
Arch Oral Biol. 2009 Nov;54(11):1068-73. doi: 10.1016/j.archoralbio.2009.08.004. Epub 2009 Sep 6.
Antigen I/II of mutans streptococcus (MS) is a surface protein, which binds to salivary receptors. The objective of this study was to study the effect of a peptide corresponding to residues 1025-1044 of antigen I/II and a dentifrice containing peptide on the adherence of MS.
The peptide was synthesized and included into dentifrice. Anti-adherence experiments of the peptide and a dentifrice containing it were processed in vitro and in vivo.
The results showed that the adherence of MS to hydroxyapatite was inhibited by synthetic antigen I/II peptide and also by a dentifrice containing the peptide in vitro. The numbers of MS in plaque from subjects treated with dentifrices containing the peptide for 1 month was significantly reduced compared to baseline (log 3.11+/-0.80 vs log 4.09+/-0.90, P<0.01), whereas the control group showed no reduction.
The adherence of MS to hydroxyapatite was inhibited by both a synthetic peptide and a dentifrice containing the peptide. The peptide dentifrice produced a significant reduction of MS in dental plaque in vivo.
变异链球菌（MS）的抗原 I/II 是一种表面蛋白，与唾液受体结合。本研究旨在研究与抗原 I/II 的残基 1025-1044 相对应的肽以及含肽牙膏对 MS 黏附的影响。
合成肽并将其纳入牙膏中。在体外和体内进行了肽和含肽牙膏的抗黏附实验。
结果表明，合成抗原 I/II 肽和含肽牙膏均可抑制 MS 对羟磷灰石的黏附。与基线相比，用含肽牙膏处理 1 个月后的受试者牙菌斑中的 MS 数量明显减少（log 3.11+/-0.80 对 log 4.09+/-0.90，P<0.01），而对照组没有减少。
合成肽和含肽牙膏均可抑制 MS 对羟磷灰石的黏附。肽牙膏在体内显著减少了牙菌斑中的 MS。
