Zimmermann R, Hülsmeyer V -I, Sauter-Louis C, Fischer A
Section of Neurology, Clinic of Small Animal Medicine, Ludwig-Maximilians-University Munich, 80539, Germany.
J Vet Intern Med. 2009 Sep-Oct;23(5):970-6. doi: 10.1111/j.1939-1676.2009.0368.x.
A special form of epileptic seizures (ES) is the life-threatening condition of status epilepticus (SE), which requires immediate and specific treatment based on a correct diagnosis of the underlying disease condition.
HYPOTHESIS/OBJECTIVES: The objectives of this retrospective study were to determine prevalence of ES and SE in dogs presenting at a veterinary teaching hospital, to identify the etiology and relative risk (RR) for SE in general and at the onset of seizures. Furthermore the outcome for dogs suffering from SE was to be evaluated.
Three hundred and ninety-four dogs that were admitted to a veterinary teaching hospital (January 1, 2002 to March 31, 2008) with ES.
All medical records of dogs with ES were identified by screening the clinical documentation system and evaluated for inclusion in this retrospective study.
Dogs with reactive seizures caused by poisoning had a significantly higher risk of developing SE (P < .001; RR = 2.74), particularly as 1st manifestation of a seizure disorder (P = .001; RR = 1.97). After SE, dogs with symptomatic epilepsy had a significantly lower probability of survival than dogs with idiopathic epilepsy (P < .001) and reactive ESs (P= .005).
In dogs showing SE as the 1st manifestation of a seizure disorder, intoxication should always be considered and appropriate investigations undertaken. Dogs with SE owing to toxicosis have more favorable outcomes than dogs with symptomatic epilepsy (P < .001).
癫痫发作（ES）的一种特殊形式是癫痫持续状态（SE），这是一种危及生命的状况，需要在正确诊断潜在疾病状况的基础上立即进行特定治疗。
假设/目的：这项回顾性研究的目的是确定在一家兽医教学医院就诊的犬只中ES和SE的患病率，确定SE总体及癫痫发作开始时的病因和相对风险（RR）。此外，还要评估患有SE的犬只的预后情况。
2002年1月1日至2008年3月31日期间因ES入住一家兽医教学医院的394只犬。
通过筛查临床文档系统识别所有患有ES的犬只的病历，并评估其是否纳入这项回顾性研究。
由中毒引起的反应性癫痫发作的犬只发生SE的风险显著更高（P < .001；RR = 2.74），尤其是作为癫痫发作障碍的首发表现时（P = .001；RR = 1.97）。发生SE后，症状性癫痫的犬只存活概率显著低于特发性癫痫的犬只（P < .001）和反应性ES的犬只（P = .005）。
对于以SE作为癫痫发作障碍首发表现的犬只，应始终考虑中毒情况并进行适当检查。因中毒导致SE的犬只比症状性癫痫的犬只预后更有利（P < .001）。
