Western Psychiatric Institute and Clinic/Pittsburgh Adolescent Alcohol Research Center, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
J Stud Alcohol Drugs. 2009 Sep;70(5):660-7. doi: 10.15288/jsad.2009.70.660.
Research on low subjective response to alcohol has focused primarily on alcohol's sedative effects during early drinking experiences. This study examined subjective response to both stimulant and sedative effects of alcohol during initial drinking experiences as predictors of treated adolescents' severity of alcohol involvement before treatment and over 1-year follow-up.
Adolescents (N = 169) recruited from addictions treatment reported on the number of drinks needed to obtain stimulant and sedative effects of alcohol for early and heavy drinking periods. The number of drinks needed to obtain stimulant and sedative effects, as well as the degree of stimulant and sedative effect obtained, were examined as predictors of adolescents' alcohol involvement at baseline (before treatment) and 1-year follow-up.
During early drinking experiences, females reported a greater degree of sedative effect compared with males; there was no gender difference in degree of stimulant effect reported during early drinking experiences. Both early subjective stimulant and sedative effects of alcohol predicted the usual number of drinks needed to become intoxicated and the maximum drinking quantity per day before treatment. However, at 1-year follow-up, only early sedative effects predicted 1-year outcomes.
Study findings suggest potentially important roles for both early subjective stimulant and sedative effects of alcohol in relation to adolescent alcohol involvement.
关于低主观酒精反应的研究主要集中在酒精在早期饮酒经历中的镇静作用上。本研究考察了在最初的饮酒经历中对酒精的兴奋剂和镇静作用的主观反应,作为治疗青少年在治疗前和 1 年随访期间酒精参与严重程度的预测指标。
从成瘾治疗中招募的青少年(N=169)报告了在早期和重度饮酒期间获得酒精的兴奋剂和镇静作用所需的饮酒量。获得兴奋剂和镇静作用所需的饮酒量,以及获得的兴奋剂和镇静作用的程度,被作为青少年在基线(治疗前)和 1 年随访时的酒精参与度的预测指标进行了研究。
在早期饮酒经历中,女性报告的镇静作用程度高于男性;在早期饮酒经历中,报告的兴奋剂作用程度没有性别差异。早期主观的酒精兴奋剂和镇静作用都预测了治疗前醉酒所需的平均饮酒量和每天的最大饮酒量。然而,在 1 年的随访中,只有早期的镇静作用预测了 1 年的结果。
研究结果表明,酒精的早期主观兴奋剂和镇静作用在青少年酒精参与度方面可能具有重要作用。