Corbin William R, Gearhardt Ashley, Fromme Kim
Department of Psychology, Yale University, 2 Hillhouse Ave, New Haven, CT 06520-8205, USA.
Psychopharmacology (Berl). 2008 Apr;197(2):327-37. doi: 10.1007/s00213-007-1039-x. Epub 2007 Dec 15.
Individual differences in subjective alcohol effects have been shown to differ by risk status (e.g., family history of alcoholism) and to predict future risk for alcohol-related problems. Presumably, individual differences in both stimulant and sedative responses affect the rewarding value of drinking which, in turn, impacts future drinking behavior. Although plausible, this theoretical model is largely untested.
The current study attempted to provide experimental evidence for the impact of subjective alcohol responses on within session drinking behavior.
Using a placebo-controlled between-subjects alcohol administration paradigm, experiences and evaluations of stimulant and sedative alcohol effects (after a target dose of 0.06 g%) were assessed as predictors of ad-libitum consumption in the context of anticipatory stress.
Analyses indicated that an initial dose of alcohol increased experiences of both stimulation and sedation although stimulant effects were evaluated much more positively. In addition, stimulant effects after a priming dose predicted further consumption, whereas sedative effects did not.
At least among moderate to heavy drinking college students, stimulant alcohol effects are more reinforcing and predict within session drinking behavior under social stress. Increased attention should be given to stimulant alcohol effects as a risk factor for excessive consumption in this population. Incorporating information about stimulant alcohol effects in prevention and intervention programs may also be important if additional research supports the current results.
主观酒精效应的个体差异已被证明因风险状态(如酒精中毒家族史)而异,并能预测未来与酒精相关问题的风险。据推测,兴奋和镇静反应的个体差异都会影响饮酒的奖赏价值,进而影响未来的饮酒行为。尽管这一理论模型看似合理,但在很大程度上尚未得到验证。
本研究试图为酒精主观反应对饮酒期间饮酒行为的影响提供实验证据。
采用安慰剂对照的组间酒精给药范式,在预期应激的背景下,评估兴奋和镇静酒精效应(目标剂量为0.06 g%后)的体验和评价,作为随意饮酒量的预测指标。
分析表明,初始剂量的酒精会增加兴奋和镇静的体验,尽管对兴奋效应的评价更为积极。此外,预充剂量后的兴奋效应可预测进一步的饮酒量,而镇静效应则不然。
至少在中度至重度饮酒的大学生中,酒精的兴奋效应更具强化作用,并能预测社交压力下饮酒期间的饮酒行为。应更多地关注酒精兴奋效应,将其作为该人群过度饮酒的一个风险因素。如果更多的研究支持当前结果,那么在预防和干预项目中纳入有关酒精兴奋效应的信息也可能很重要。