Department of Psychiatry, Joondi Shapoor University of Medical Sciences, Ahwaz, Iran.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1513-6. doi: 10.1016/j.pnpbp.2009.08.021. Epub 2009 Sep 6.
Traditionally, the dried flower of Echium amoenum (Boraginaceae) has been used in Iran as an anxiolytic and mood enhancer. This study investigated the efficacy and safety of an aqueous extract of E. amoenum in treatment of obsessive-compulsive disorder. Forty-four patients were randomly assigned to receive either E. amoenum aqueous extract (500 mg/day) or placebo in a 6-week, double blind, parallel-group trial. Patients were assessed before the study and during weeks 1, 2, 4, and 6 by the Yale-Brown Obsessive Compulsive (Y-BOCS), the Hamilton Rating Scale for Anxiety (HAM-A), and a score sheet on adverse effects. In weeks 4 and 6, the extract showed a significant superiority over placebo in reducing obsessive and compulsive and anxiety symptoms. There was no significant difference between the two groups in terms of adverse effects. The results suggest that E. amoenum aqueous extract has some anti obsessive and compulsive effects. However, further studies are needed to confirm these findings.
传统上，蓝蓟（紫草科）的干花在伊朗被用作抗焦虑和情绪增强剂。本研究调查了蓝蓟水提物治疗强迫症的疗效和安全性。44 名患者被随机分配接受蓝蓟水提物（500mg/天）或安慰剂治疗，为期 6 周的双盲、平行组试验。在研究前和第 1、2、4 和 6 周，患者分别接受耶鲁-布朗强迫症量表（Y-BOCS）、汉密尔顿焦虑量表（HAM-A）和不良反应评分表评估。在第 4 和 6 周，提取物在减轻强迫和焦虑症状方面明显优于安慰剂。两组在不良反应方面无显著差异。结果表明，蓝蓟水提物具有一定的抗强迫作用。然而，需要进一步的研究来证实这些发现。
