• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR.解脲支原体株的药敏试验采用肉汤稀释法和定量 PCR 检测。
Antimicrob Agents Chemother. 2009 Nov;53(11):4938-9. doi: 10.1128/AAC.00724-09. Epub 2009 Sep 8.
2
Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR.运用TaqMan 5'核酸酶实时PCR对生殖支原体进行抗生素敏感性测试。
Antimicrob Agents Chemother. 2005 Dec;49(12):4993-8. doi: 10.1128/AAC.49.12.4993-4998.2005.
3
Identification of treatment strategies for Mycoplasma genitalium-related urethritis in male patients by culturing and antimicrobial susceptibility testing.通过培养和药敏试验鉴定男性患者解脲支原体相关尿道炎的治疗策略。
J Infect Chemother. 2013 Feb;19(1):1-11. doi: 10.1007/s10156-012-0487-3. Epub 2012 Oct 18.
4
Sitafloxacin: antimicrobial activity against ciprofloxacin-selected laboratory mutants of Mycoplasma genitalium and inhibitory activity against its DNA gyrase and topoisomerase IV.西他沙星：对环丙沙星筛选的生殖支原体实验室突变株的抗菌活性及其对DNA促旋酶和拓扑异构酶IV的抑制活性。
J Infect Chemother. 2015 Jan;21(1):74-5. doi: 10.1016/j.jiac.2014.08.021. Epub 2014 Sep 22.
5
In vitro activity of zoliflodacin (ETX0914) against macrolide-resistant, fluoroquinolone-resistant and antimicrobial-susceptible Mycoplasma genitalium strains.唑利福霉素（ETX0914）对大环内酯类耐药、氟喹诺酮类耐药和抗菌药物敏感的生殖支原体菌株的体外活性。
J Antimicrob Chemother. 2018 May 1;73(5):1291-1294. doi: 10.1093/jac/dky022.
6
In vitro activity of azithromycin against Mycoplasma genitalium and its efficacy in the treatment of male Mycoplasma genitalium-positive nongonococcal urethritis.体外研究阿奇霉素对生殖支原体的活性及其治疗男性生殖支原体阳性非淋菌性尿道炎的疗效。
J Infect Chemother. 2011 Dec;17(6):821-4. doi: 10.1007/s10156-011-0269-3. Epub 2011 Jun 28.
7
Mutations in ParC and GyrA of moxifloxacin-resistant and susceptible Mycoplasma genitalium strains.耐莫昔沙星和敏感的支原体生殖器菌株中 ParC 和 GyrA 的突变。
PLoS One. 2018 Jun 8;13(6):e0198355. doi: 10.1371/journal.pone.0198355. eCollection 2018.
8
Clinical and analytical evaluation of the new Aptima Mycoplasma genitalium assay, with data on M. genitalium prevalence and antimicrobial resistance in M. genitalium in Denmark, Norway and Sweden in 2016.2016 年丹麦、挪威和瑞典的泌尿生殖道支原体感染及耐药情况和新型 Aptima 解脲支原体检测的临床和分析评估
Clin Microbiol Infect. 2018 May;24(5):533-539. doi: 10.1016/j.cmi.2017.09.006. Epub 2017 Sep 18.
9
activity of the first-in-class triazaacenaphthylene gepotidacin alone and in combination with doxycycline against drug-resistant and -susceptible .第一类三氮杂萘并嘧啶 gepotidacin 单独及与多西环素联合用于治疗耐药和敏感.
Emerg Microbes Infect. 2020 Dec;9(1):1388-1392. doi: 10.1080/22221751.2020.1775498.
10
Antimicrobial efficacies of several antibiotics against uterine cervicitis caused by Mycoplasma genitalium.几种抗生素对解脲支原体引起的宫颈炎的抗菌疗效。
J Infect Chemother. 2012 Jun;18(3):313-7. doi: 10.1007/s10156-011-0329-8. Epub 2011 Oct 22.

引用本文的文献

1
Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant Mycoplasma genitalium.米诺环素和甲硝唑联合用药治疗对大环内酯类耐药的生殖支原体的疗效和耐受性
J Antimicrob Chemother. 2025 Jul 1;80(7):1878-1884. doi: 10.1093/jac/dkaf142.
2
test of the novel antibiotic lefamulin alone and in combination with doxycycline against .新型抗生素乐伐莫林单独及与多西环素联合使用对……的试验
Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0134624. doi: 10.1128/aac.01346-24. Epub 2024 Dec 13.
3
Efficacy of Minocycline for the Treatment of .米诺环素治疗……的疗效
Open Forum Infect Dis. 2023 Aug 11;10(8):ofad427. doi: 10.1093/ofid/ofad427. eCollection 2023 Aug.
4
Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens.评估真菌来源的黄烷酮作为针对具有不同进化亲缘关系的人类病原体的广谱抗感染药物。
J Nat Prod. 2023 Jun 23;86(6):1596-1605. doi: 10.1021/acs.jnatprod.3c00283. Epub 2023 Jun 5.
5
Susceptibility and Resistance of Mycoplasma genitalium to Nitroimidazoles.生殖支原体对硝基咪唑类药物的敏感性和耐药性。
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0000623. doi: 10.1128/aac.00006-23. Epub 2023 Mar 9.
6
Mutations in ParC and GyrA of moxifloxacin-resistant and susceptible Mycoplasma genitalium strains.耐莫昔沙星和敏感的支原体生殖器菌株中 ParC 和 GyrA 的突变。
PLoS One. 2018 Jun 8;13(6):e0198355. doi: 10.1371/journal.pone.0198355. eCollection 2018.
7
infections: current treatment options and resistance issues.感染：当前的治疗选择与耐药问题
Infect Drug Resist. 2017 Sep 1;10:283-292. doi: 10.2147/IDR.S105469. eCollection 2017.
8
New Horizons in Mycoplasma genitalium Treatment.生殖支原体治疗的新视野
J Infect Dis. 2017 Jul 15;216(suppl_2):S412-S419. doi: 10.1093/infdis/jix132.
9
Multidrug-resistant Mycoplasma genitalium infections in Europe.欧洲耐多药生殖支原体感染。
Eur J Clin Microbiol Infect Dis. 2017 Sep;36(9):1565-1567. doi: 10.1007/s10096-017-2969-9. Epub 2017 Mar 30.
10
Antimicrobial Susceptibility Patterns of Recent Cuban Mycoplasma genitalium Isolates Determined by a Modified Cell-Culture-Based Method.采用改良的基于细胞培养的方法测定古巴近期生殖支原体分离株的抗菌药敏模式。
PLoS One. 2016 Sep 28;11(9):e0162924. doi: 10.1371/journal.pone.0162924. eCollection 2016.

本文引用的文献

1
Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance.阿奇霉素治疗解脲脲原体阳性的非淋菌性尿道炎患者失败与诱导产生大环内酯类耐药有关。
Clin Infect Dis. 2008 Dec 15;47(12):1546-53. doi: 10.1086/593188.
2
Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study.阿奇霉素和莫西沙星用于生殖支原体感染的微生物学治愈：一项开放性研究。
Int J STD AIDS. 2008 Oct;19(10):676-9. doi: 10.1258/ijsa.2008.008038.
3
Activity of moxifloxacin against the urogenital mycoplasmas Ureaplasma spp., Mycoplasma hominis and Mycoplasma genitalium and Chlamydia trachomatis.莫西沙星对泌尿生殖支原体脲原体属、人型支原体、生殖支原体及沙眼衣原体的活性。
Clin Microbiol Infect. 2008 Aug;14(8):801-5. doi: 10.1111/j.1469-0691.2008.02027.x.
4
Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial.斯堪的纳维亚地区有症状的生殖支原体感染的抗生素治疗：一项对照临床试验。
Sex Transm Infect. 2008 Feb;84(1):72-6. doi: 10.1136/sti.2007.027375. Epub 2007 Oct 11.
5
Isolation of Mycoplasma genitalium from first-void urine specimens by coculture with Vero cells.通过与非洲绿猴肾细胞共培养从首次晨尿标本中分离生殖支原体。
J Clin Microbiol. 2007 Mar;45(3):847-50. doi: 10.1128/JCM.02056-06. Epub 2007 Jan 24.
6
Azithromycin failure in Mycoplasma genitalium urethritis.阿奇霉素治疗解脲脲原体尿道炎失败
Emerg Infect Dis. 2006 Jul;12(7):1149-52. doi: 10.3201/eid1207.051558.
7
Sequence-based typing of Mycoplasma genitalium reveals sexual transmission.基于序列的生殖支原体分型揭示了性传播。
J Clin Microbiol. 2006 Jun;44(6):2078-83. doi: 10.1128/JCM.00003-06.
8
Mycoplasma genitalium infections. Diagnosis, clinical aspects, and pathogenesis.生殖支原体感染。诊断、临床特征及发病机制。
Dan Med Bull. 2006 Feb;53(1):1-27.
9
Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR.运用TaqMan 5'核酸酶实时PCR对生殖支原体进行抗生素敏感性测试。
Antimicrob Agents Chemother. 2005 Dec;49(12):4993-8. doi: 10.1128/AAC.49.12.4993-4998.2005.
10
Emergence of macrolide-resistant Mycoplasma pneumoniae with a 23S rRNA gene mutation.具有23S rRNA基因突变的大环内酯类耐药肺炎支原体的出现。
Antimicrob Agents Chemother. 2005 Jun;49(6):2302-6. doi: 10.1128/AAC.49.6.2302-2306.2005.

解脲支原体株的药敏试验采用肉汤稀释法和定量 PCR 检测。

Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR.

机构信息

Department of Urology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.

出版信息

Antimicrob Agents Chemother. 2009 Nov;53(11):4938-9. doi: 10.1128/AAC.00724-09. Epub 2009 Sep 8.

DOI:10.1128/AAC.00724-09
PMID:19738019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2772321/
Abstract

Only limited information regarding the antimicrobial susceptibilities of Mycoplasma genitalium is available because of difficulties in isolating M. genitalium strains from clinical specimens. Antimicrobial susceptibilities of 15 clinical isolates, 7 ATCC strains, and an early passage of the M30 strain were examined by the broth dilution method. Azithromycin, clarithromycin, sitafloxacin, and moxifloxacin were the most active drugs against M. genitalium, and their MIC(90)s were 0.002, 0.008, 0.125, and 0.125 mg/liter, respectively.

摘要

由于从临床标本中分离支原体属生殖器株存在困难，因此有关支原体属生殖器的药敏数据有限。采用肉汤稀释法检测了 15 株临床分离株、7 株 ATCC 株和 M30 株的早期传代株的药敏情况。阿奇霉素、克拉霉素、司帕沙星和莫西沙星对支原体属生殖器的活性最强，其 MIC90 分别为 0.002、0.008、0.125 和 0.125 mg/L。