Waters M D, Claxton L D, Stack H F, Brady A L, Graedel T E
Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Teratog Carcinog Mutagen. 1990;10(2):147-64. doi: 10.1002/tcm.1770100211.
Some knowledge of the potential genetic activity of a complex environmental mixture may be gained from an assessment of the genetic activity of its component chemicals. The expanded Genetic Activity Profile (GAP) data base provides a computer-generated graphic representation of genetic bioassay data as a function of dose of the substance tested. In addition, the Atmospheric Chemical Compound (ACC) data-base contains information on chemical structures, properties, detection methods, and sources of chemicals found in ambient air. Using the combined data bases, the quantity of an individual chemical present within a mixture or fraction of a mixture may be related to the quantity (lowest effective dose, LED) of the chemical, by itself, required to demonstrate a positive response in one or more genetic bioassays.
通过评估复杂环境混合物中各成分化学物质的遗传活性，或许能够获得有关该混合物潜在遗传活性的一些知识。扩展的遗传活性概况（GAP）数据库以计算机生成的图形形式呈现遗传生物测定数据，该数据是所测试物质剂量的函数。此外，大气化合物（ACC）数据库包含有关化学结构、性质、检测方法以及环境空气中发现的化学物质来源的信息。利用这两个合并的数据库，混合物或混合物组分中单个化学物质的含量可与该化学物质自身在一种或多种遗传生物测定中显示阳性反应所需的量（最低有效剂量，LED）相关联。
