Matsumoto Shinya, Akahane Manabu, Kanagawa Yoshiyuki, Koike Soichi, Yoshimura Takesumi, Mitoma Chikage, Shibata Satoko, Uchi Hiroshi, Furue Masutaka, Imamura Tomoaki
Department of Planning Information and Management, The University of Tokyo Hospital, Tokyo, Japan.
Chemosphere. 2009 Oct;77(5):658-62. doi: 10.1016/j.chemosphere.2009.08.009. Epub 2009 Sep 11.
Yusho (oil disease) is the name given to a food poisoning incident caused by rice bran oil that occurred in west Japan in 1968. The causative agents of Yusho are currently considered to be polychlorinated biphenyls (PCBs) and their by-products, such as dioxin like compounds. The levels of 2,3,4,7,8-penta-cholorodibenzofuran (PeCDF) are measured in the blood of Yusho patients who attend medical check-ups. The objectives of this study were to determine the half-life of PeCDF in these patients. Linear regression analysis was performed with the binary logarithm of PeCDF blood levels in Yusho patients as the dependent variable and the measurement year as the independent variable. The linear coefficient determined in this analysis is the reciprocal of the half-life. The half-life of PeCDF varied among patients. Among patients with PeCDF blood levels of 50pgg(-1) or higher, there were two groups: one showing a half-life of approximately 7 years and the other showing no reduction in PeCDF levels over time. The results indicate that there is a group of patients whose PeCDF levels are maintained at a high level. Our study suggests that a more complicated model is required to explain PeCDF excretion in humans.
油症是1968年发生在日本西部的一起由米糠油引起的食物中毒事件的名称。目前认为油症的致病因子是多氯联苯（PCBs）及其副产物，如二噁英类化合物。对前来进行体检的油症患者的血液中2,3,4,7,8-五氯二苯并呋喃（PeCDF）的水平进行了测量。本研究的目的是确定这些患者体内PeCDF的半衰期。以油症患者血液中PeCDF水平的常用对数为因变量、测量年份为自变量进行线性回归分析。该分析中确定的线性系数是半衰期的倒数。PeCDF的半衰期在患者之间存在差异。在血液中PeCDF水平达到50pg g⁻¹或更高的患者中，有两组：一组的半衰期约为7年，另一组的PeCDF水平并未随时间降低。结果表明，有一组患者的PeCDF水平维持在较高水平。我们的研究表明，需要一个更复杂的模型来解释人体中PeCDF的排泄情况。
