Department of Physical Education, National Defense Academy, Kanagawa, Japan.
J Atheroscler Thromb. 2009;16(6):733-9. doi: 10.5551/jat.2089. Epub 2009 Sep 14.
To determine the effects of exercise training on total and high molecular weight (HMW) adiponectin and adiponectin oligomeric distribution.
A randomized parallel-design study (n=53; 40 women and 13 men; age range, 32?65 years) was conducted at a fitness club between April 2006 and July 2007. Participants were randomly assigned to the exercise (n=26) or control (n=27) group and received exercise training for 70 min 2 times per week for 12 weeks and exercise advice at the baseline, respectively. The primary outcomes were changes in total adiponectin, HMW adiponectin and percentage of HMW adiponectin.
Muscle strength improved in the exercise group but remained stable in the control group. Body weight and BMI were not modified by exercise training. After 12 weeks, there were no differences between groups in total adiponectin levels, HMW adiponectin levels, or percentage of HMW adiponectin.
In the absence of weight loss, twice-weekly exercise training does not change HMW adiponectin levels or the adiponectin oligomer composition.
确定运动训练对总及高分子量（HMW）脂联素和脂联素寡聚体分布的影响。
本研究于 2006 年 4 月至 2007 年 7 月在一家健身俱乐部开展了一项随机平行设计研究（n=53；40 名女性和 13 名男性；年龄范围 32-65 岁）。参与者被随机分配至运动（n=26）或对照组（n=27），并分别接受为期 12 周、每周 2 次、每次 70 分钟的运动训练和基线时的运动建议。主要结局为总脂联素、高分子量脂联素和高分子量脂联素百分比的变化。
运动组的肌肉力量得到改善，而对照组则保持稳定。体重和 BMI 均未因运动训练而改变。12 周后，两组间总脂联素水平、高分子量脂联素水平或高分子量脂联素百分比均无差异。
在不减轻体重的情况下，每周两次的运动训练不会改变 HMW 脂联素水平或脂联素寡聚体组成。
