Bajaj Doulat Rai, Mahesar Shah Muhammad, Devrajani Bekha Ram, Iqbal Muhammad Pervaiz
Department of Dermatology, Liaquat University of Medical & Health Sciences, Jamshoro, Hyderabad.
J Pak Med Assoc. 2009 Aug;59(8):512-5.
To determine the lipid abnormalities in patients with psoriasis and compare it with healthy controls.
Across-sectional controlled study was conducted at the Department of Dermatology Liaquat University Hospital Hyderabad from January 2007 to November 2007. The study included 158 consecutive patients; among which 88 were males (44 patients and 44 controls) and 70 females (35 patients and 35 controls). The patients with psoriasis having less than 30% body involvement were included in the study. Patients with severe psoriasis, high BMI (.30 kg/m2), hypertension, diabetes, smoking, alcohol consumption and personal or family history of hyperlipedemia were excluded. The patients were examined clinically and findings recorded on a pre-designed proforma. Fasting lipids were measured using SELECTRA XL chemistry analyzer using Spin react kits (made in Spain) by direct method.
All patients had psoriasis involving less than 30% of body surface. Their ages ranged from 18 years to 68 years (mean 37 +/- 7.96 years). Family history of disease was positive in 10 (6.32%) patients. 134 (84.8%) had plaque type psoriasis, 10 (6%) had in addition scalp and nail involvement, 05 (3.16%) guttate lesions, 05 (3.16%) had palmoplantar lesions while remaining 04 (2.43%) comprised of hyperkeratotic and flexural psoriasis. The duration of disease ranged between 18 months to 10 years with a mean of 4.5 +/- 1.89 years. Serum cholesterol, triglycerides and low density lipoprotein (LDL) cholesterol were significantly higher than in the normal control group (P < 0.01). There was no significant statistical difference in serum levels of very low density lipoprotein cholesterol (VLDL) and high density lipoprotein cholesterol (HDL-C) between the two groups.
Psoriasis is an independent risk factor for hyperlipidaemia and its possible subsequent sequelae such as obstructive vascular disease.
确定银屑病患者的脂质异常情况，并与健康对照者进行比较。
2007年1月至2007年11月在海得拉巴利亚卡特大学医院皮肤科进行了一项横断面对照研究。该研究纳入了158例连续患者；其中男性88例（44例患者和44例对照），女性70例（35例患者和35例对照）。银屑病累及身体面积小于30%的患者被纳入研究。排除患有严重银屑病、高BMI（>30kg/m²）、高血压、糖尿病、吸烟、饮酒以及有高脂血症个人或家族史的患者。对患者进行临床检查，并将结果记录在预先设计的表格上。使用西班牙制造的Spin react试剂盒，通过直接法，采用SELECTRA XL化学分析仪测量空腹血脂。
所有患者的银屑病累及身体表面积均小于30%。他们的年龄在18岁至68岁之间（平均37±7.96岁）。10例（6.32%）患者有家族病史。134例（84.8%）为斑块型银屑病，10例（6%）除头皮和指甲受累外，5例（3.16%）为点滴状皮损，5例（3.16%）有掌跖皮损，其余4例（2.43%）为角化过度型和屈侧银屑病。病程在18个月至10年之间，平均为4.5±1.89年。血清胆固醇、甘油三酯和低密度脂蛋白（LDL）胆固醇显著高于正常对照组（P<0.01）。两组之间极低密度脂蛋白胆固醇（VLDL）和高密度脂蛋白胆固醇（HDL-C）的血清水平无显著统计学差异。
银屑病是高脂血症及其可能的后续后遗症（如阻塞性血管疾病）的独立危险因素。
